灵芝多糖的抗肿瘤活性及免疫效应  

The Antitumor Activity and Immune Effect of Ganoderma lucidum Polysaccharides

作　　者：闵三弟[1] 臧珍娣 宋士良[1] 劳华均[1] 严惠芳[2] 陆宏祺[2] 

机构地区：[1]上海市农业科学院食用菌研究所,上海201106 [2]上海医药工业研究院药理室,上海200437

出　　处：《食用菌学报》1996年第1期21-26,共6页Acta Edulis Fungi

摘　　要：从灵芝子实体用热水提取分离的灵芝多糖（GLP）对Lewis肺癌和结肠癌具有相当高的抑制生长活性,并能增强正常小鼠腹腔巨噬细胞吞噬作用和荷瘤小鼠NK细胞活性,从而提高机体免疫功能.灵芝多糖口服给药剂量每天每公斤C57BL/6小鼠2000mg.足趾接种和腑皮下接种对Lewis肺癌的抑制率分别为53.54％～59.13 ％和36.43％～42.76％;对结肠癌的抑制率分别为42.47％～49.14％和29.43％～32.09％.The polysaccharide of Ganoderma lucidum (GLP), isolated from hot-water extracts of Ganoderma lucidum fruitbody has relatively high growth-inhibition activities against Lewis lung carcinoma and colon cancer and enhances immune function of the mice which took it. GLP is taken orally by C57BL/6 mice at a dosage of 2000mg per day and the inhibition rate of Lewis lung carcinoma by subcutaneous inoculation to mice at toe and axillary is about 53.54 %-59.13 % and 36.43 %-42.76 % respectively. The inhibition rate of colon cancer by inoculation to mice at toe and axillary is about 42.47% -49.13% and 29.43-32.09% respectively. Meanwhile, GLP enhances the phagocytosis of macrophage in abdominal cavity of normal mice and activities of NK cells of tumor-bearing mice.

关 键 词：灵芝 子实体 多糖 抗肿瘤活性 

分 类 号：R282.710.5[医药卫生—中药学] O629.12[医药卫生—中医学]