Recombinant adeno-associated virus-mediated inhibiting of interleukin-4 expression in rat model of asthma  

作　　者：CAO Yong XIONG Wei-ning XU Yong-jian ZHANG Zhen-xiang GAO Bao-an DU Chun-ling LU Jun-yu YE Tao 

机构地区：[1]Department of Respiratory Medicine, Tongji Hospital, TongjiMedical College, Huazhong University of Science and Technology,Wuhan 430030, China

出　　处：《Chinese Medical Journal》2006年第3期223-225,共3页中华医学杂志（英文版）

基　　金：This study was supported by a grant from the National Natural Science Foundation of China(No. 30300144).

摘　　要：Asthma is a chronic disease characterized by ,reversible airway obstruction, airway hyperresponsiveness, and inflammation of airways, Th2 cells, one sort of CD4＋ T lymphocytes, are currently considered to play an important role in the chronic airway inflammation of asthma, Meanwhile, a number of laboratories have clearly established the importance of the Th2-dedved cytokine interleukin-4 （IL-4） in mediating the airway inflammatory response, Anti-IL-4 therapy might be beneficial in treatment of chronic asthma.Asthma is a chronic disease characterized by ,reversible airway obstruction, airway hyperresponsiveness, and inflammation of airways, Th2 cells, one sort of CD4＋ T lymphocytes, are currently considered to play an important role in the chronic airway inflammation of asthma, Meanwhile, a number of laboratories have clearly established the importance of the Th2-dedved cytokine interleukin-4 （IL-4） in mediating the airway inflammatory response, Anti-IL-4 therapy might be beneficial in treatment of chronic asthma.

关 键 词：adeno-associated virus INTERLEUKIN-4 ASTHMA 

分 类 号：R562.25[医药卫生—呼吸系统]