A Convenient Synthesis of Antibacterial Linezolid from (S)-Glyceraldehyde Acetonide  

作　　者：Guang Yu XU Yi ZHOU Man Cai XU 

机构地区：[1]College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081

出　　处：《Chinese Chemical Letters》2006年第3期302-304,共3页中国化学快报（英文版）

摘　　要：A convenient synthesis of oxazolidinone antibacterial linezolid from readily available L-ascorbic acid is described. The key steps include reductive amination of arylamine and （S）-glyceraldehyde acetonide in the presence of NaBH4 and 4A sieve, followed by hydrolysis and regioselective cyclization.A convenient synthesis of oxazolidinone antibacterial linezolid from readily available L-ascorbic acid is described. The key steps include reductive amination of arylamine and （S）-glyceraldehyde acetonide in the presence of NaBH4 and 4A sieve, followed by hydrolysis and regioselective cyclization.

关 键 词：LINEZOLID ANTIBACTERIAL SYNTHESIS ascorbic acid. 

分 类 号：R978.1[医药卫生—药品] R977.23[医药卫生—药学]