视神经炎引起视神经纤维层轴突丧失及视功能障碍  

Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis

作　　者：Trip S.A. Schlottmann P.G. Jones S.J. 杨秀梅 

机构地区：[1]Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom Dr

出　　处：《世界核心医学期刊文摘（眼科学分册）》2006年第1期1-1,共1页Digest of the World Core Medical Journals:Ophthalmology

摘　　要：Axonal loss is thought to be a likely cause of persistent disability after amultiple sclerosis relapse; therefore, noninvasive in vivo markers specific for axonal loss are needed. We used optic neuritis as a model of multiple sclerosis relapse to quantify axonal loss of the retinal nerve fiber layer (RNFL) and secondary retinal ganglion cell loss in die macula with optical coherence tomography. We studied 25 patients who had a previous single episode of optic neuritis with a recruitment bias to those with incomplete recovery and 15 control subjects. Optical coherence tomography measurement of RNFL thickness and macular volume, quantitative visual testing, and electrophysiological examination were performed. There were highly significant reductions (P < 0.001) of RNFL thic kness and macular volume in affected patient eyes compared with control eyes and clinically unaffected fellow eyes. There were significant relationships among RNFL thicknessand visual acuity, visual field, color vision, and visual evoked potential amplitude. This study has demonstrated functionally relevant changes indicative of axonal loss and retinal ganglion cell loss in the RNFL and macula, respectively, after optic neuritis. This noninvasive RNFL imaging technique could be used in trials of experimental treatments that aim to protect optic nerves from axonal loss.Axonal loss is thought to be a likely disability after a multiple sclerosis cause of relapse pemistent therefore, noninvasive in vivo markers specific for axonal loss are needed. We used optic neuritis as a model of multiple sclerosis relapse to quantify axonal loss of the retinal nerve fiber layer （RNFL） and secondary retinal ganglion cell loss in die macula with optical coherence tomography. We studied 25 patients who had a previous single episode of optic neuritis with a recruitment bias to those with incomplete recovery and 15 control subjects. Optical coherence tomography measurement of RNFL thickness and macular volume, quantitative visual testing, and electrophysiological examination were performed. There were highly signif- icant reductions （P 〈 0. 001） of RNFL thickness and macular volume in affected patient eyes compared with control eyes and clinically unaffected fellow eyes. There were significant relationships among RNFL thickness and visual acuity, visual field, color vision, and visual-evoked potential amplitude. This study has demonstrated functionally relevant changes indicative of axonal loss and retinal ganglion cell loss in the RNFL and macula, respectively, after optic neuritis. This noninvasive RNFL imaging technique could be used in trials of experimental treatments that aim to protect optic nerves from axonal loss.

关 键 词：视神经纤维层 轴突丧失 视神经炎 视功能障碍 光学相干断层扫描 多发性硬化症 视觉电生理检查 NFL厚度 特异性标记物 定量分析 

分 类 号：R775[医药卫生—眼科] R744.51[医药卫生—临床医学]