种植前牙槽骨保存的动物实验  

An experimental study on alveolar ridge preservation prior to dental implant placement

作　　者：施斌[1] 周毅[1] 王贻宁[1] 程祥荣[2] 

机构地区：[1]武汉大学口腔医学院口腔生物医学工程教育部重点实验室,430079 [2]武汉大学口腔医学院口腔生物医学工程教育部修复科,430079

出　　处：《中华口腔医学杂志》2006年第2期114-115,共2页Chinese Journal of Stomatology

基　　金：湖北省科技攻关计划基金资助项目(2004AA304B07)

摘　　要：目的探讨外科级半水硫酸钙(SGCS)和富血小板血浆(PRP)复合物在种植前牙槽骨保存中应用的可行性。方法利用SGCS和PRP复合物、SGCS植入5只犬两侧手术区后,采用螺旋CT、放射性核素骨显像、X线片、组织学和组织形态计量技术,比较牙槽骨修复后的变化。结果SGCS和PRP复合物减小了牙槽骨吸收,提高了新骨生成的代谢活性和种植体的骨结合率。而在SGCS中加入PRP仅在早期表现出较高的骨代谢活性。结论在本项实验中,SGCS和PRP复合物可用于种植前牙槽骨的保存。Objective To evaluate the combination of surgical grade calcium sulfate hemihydrate （SGCS） and platelet-rich plasma （PRP） for alveolar ridge preservation prior to implant placement. Methods Changes of bone quantity andquality in extraction sites following the SGCS/PRP and SGCS implantations were investigated by spiral computer tomography scan, bone scintigraphy, radiographic, histological and histomorphometric examinations. Results The placement of SGCS/PRP reduced the resorption of the alveolar ridge. It also promoted bone metabolism and bone-to-implant contact. The addition of PRP to SGCS achieved the enhancement of the bone metabolism only at the early healing phase. Conclusions In this animal experiment, SGCS/PRP may be used as fresh extraction sockets graft for alveolar ridge preservation prior to implant placement.

关 键 词：牙种植 牙槽骨质丢失 硫酸钙 富血小板血浆 

分 类 号：R783.6[医药卫生—口腔医学] R780.2[医药卫生—临床医学]