阿尔茨海默病患者FGF1基因启动子-1385A/G多态与ApoE基因多态关联性分析  

Analysis of the interaction of the-1385A/G polymorphisms of FGF1 gene promoter and ApoE gene in Alzheimer's disease

作　　者：姚丽芬[1] 李克深[2] 张黎明[1] 王德生[1] 宋琳[3] 谢宁[3] 

机构地区：[1]哈尔滨医科大学附属第一医院神经内科,150001 [2]哈尔滨医科大学医学遗传教研室 [3]黑龙江中医药大学

出　　处：《中华神经科杂志》2006年第2期89-91,共3页Chinese Journal of Neurology

摘　　要：目的探讨成纤维细胞生长因子1（FGF1）基因启动子，载脂蛋白E（ApoE）基因多态性在散发性阿尔茨海默病（sporadic Alzheimer disease，SAD）发病机制中的作用。方法应用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法检测41例SAD患者和43名健康人中FGF1基因启动子和ApoE基因多态性分布，并通过比值比（OR）对这两种基因与AD之间进行关联性分析。结果FGF1基因启动子多态性（-1385A／G）与AD的发病风险显著相关；GG基因型与非GG基因型的OR=3．15，95％ CI=1．08～5．46。SAD患者与ApoE基因的等位基因ε4正关联，ApoE ε4与非ε4的OR=4．02，95％ CI=1．64～9．52。在ApoE ε4中携带FGF1 GG基因型的OR=15．22，95％ CI=6．68～40．58。结论FGF1基因启动子-1385A／G多态可能是SAD发病的遗传危险因素，FGF1启动子多态与ApoE基因多态性之间有协同作用，ApoE ε4等位基因与FGF1 GG基因型同时存在时，患AD的危险性显著提高。Objective To explore the association between FGF1 promoter and APOE gene polymorphisms and sporadic Alzheimer＇s disease （SAD）. Methods The polymorphisms of FGF1 promoter and ApoE gene were determined in 41 SAD patients and 43 normal controls by PCR-RFLP method. Results The promoter polymorphism （-1385A/G） was significantly associated with SAD risk. The odds ratio for AD associated with the GG vs non-GG genotype was 3.15 （95% CI = 1.08～5.46）, while that of ε4 vs non-ε4 in ApoE gene was 4.02 （95% CI = 1.64～9.52）. The odds ratio for ApoE ε4 and FGF1 GG carriers was 15.22 （95% CI = 6.68～40.58）. Condusion FGF1 promoter -1385A/G polymorphism may be an independent genetic risk factor for SAD in Chinese, and the onset of SAD is associated with the interaction of the polymorphisms of FGF1 promoter and ApoE gene.

关 键 词：阿尔茨海默病 成纤维细胞生长因子1 载脂蛋白E类 多态性 限制性片段长度 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R575.2[医药卫生—临床医学]