Her-2/neu基因过表达与胃癌生物学行为的关系研究  

Relationship between the overexpression of Her-2/neu gene and biologic behavior of human gastric carcinoma

作　　者：王建红[1] 何松[1] 陈冬梅[1] 谭清和[1] 龚振夏[1] 朱亚芳[1] 

机构地区：[1]南通市肿瘤医院内科

出　　处：《临床肿瘤学杂志》2006年第2期105-109,共5页Chinese Clinical Oncology

摘　　要：目的:了解Her-2/neu基因过表达与胃癌生物学行为的关系。方法:应用免疫组化法检测了具有随访资料的164例胃癌标本的Her-2/neu基因的表达状态。结果:164例胃癌的Her-2/neu基因过表达率为19·51%,其过表达与患者的性别、年龄、肿瘤生长的部位、分化程度、浸润深度、脉管内癌细胞的浸润、UICC分期均无关(P>0·05);仅与胃癌的病理类型密切相关(P<0·05);且Her-2/neu基因过表达与胃癌的预后无关,胃癌的预后仅与胃癌的浸润深度和UICC分期有关。结论:胃癌Her-2/neu基因过表达似与胃癌的病理类型密切相关,预后与肿瘤的浸润深度和UICC分期有关。Objective：To learn the relationship between the overexpression of Her-2/neu gene and biologic behavior of human gastric carcinoma. Methods：Overexpression of Her-2/neu gene in 164 follow-up cases of human gastric carcinoma specimens were detected by immunhistochemistry. Results：The overexpression incidence of Her-2/neu gene in these specimens was 19. 51% ,the overexpression didn＇t show a significant correlation to patients＇sex age, location of the carcinoma, infiltration depth, differentiated degree, infiltration of carcinoma cells in vessels and UICC staging. （P 〉 0. 05 ）, only has a closely relationship with the pathological type of gastric carcinoma. （ P 〈 0. 05 ） ;while overexpression of Her-2/neu gene was irrelated to prognosis of gastric carcinoma. The prognosis was related to the infiltration of carcinoma and the UICC staging. Conclusion：The overexpression of Her-2/neu gene in gastric carcinoma has a closely relationship with the pathologic type of gastric carcinoma,the prognosis of gastric carcinoma was related to the infiltration depth and UICC stsging.

关 键 词：胃癌 HER-2/NEU基因 生物学行为 

分 类 号：R730.51[医药卫生—肿瘤]