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机构地区:[1]武汉华中科技大学同济医学院附属协和医院耳鼻喉科,430022
出 处:《The Chinese-German Journal of Clinical Oncology》2006年第1期18-19,共2页中德临床肿瘤学杂志(英文版)
基 金:This work was supported by a grant from the National Natural Science Foundation of China(No. 30070809).
摘 要:Objective: To investigate the expression of K-ras in human laryngeal squamous cell carcinoma cell lines (Hep-2) and its significance for establishing a solid foundation for further study of the relationship between human laryngeal squamous cell carcinoma and K-ras gene point mutations. Methods: The expression of K-ras in human laryngeal squamous cell carcinoma cell lines (Hep-2) and human pancreatic carcinoma cell lines (MIAPaCa-2) was detected by using RT-PCR. Results: The expression of K-ras mRNA in Hep-2 and MIAPaCa-2 was strong and positive. Conclusion: The expression of K-ras mRNA in human laryngeal squamous cell carcinoma cell lines (Hep-2) is positive. Development of laryngeal carcinoma might be related to the activation of K-ras gene point mutation.
关 键 词:K-RAS human laryngeal squamous cell carcinoma cell lines (Hep-2) RT-PCR
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