Relation between the Expression of K-ras in Hep-2 Cells and Development of Laryngeal Carcinoma~*  

K-ras基因在人喉鳞状细胞癌细胞株(Hep-2)中的表达及其意义

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作  者:陈雄[1] 孔维佳[1] 张苏琳 张丹[1] 

机构地区:[1]武汉华中科技大学同济医学院附属协和医院耳鼻喉科,430022

出  处:《The Chinese-German Journal of Clinical Oncology》2006年第1期18-19,共2页中德临床肿瘤学杂志(英文版)

基  金:This work was supported by a grant from the National Natural Science Foundation of China(No. 30070809).

摘  要:Objective: To investigate the expression of K-ras in human laryngeal squamous cell carcinoma cell lines (Hep-2) and its significance for establishing a solid foundation for further study of the relationship between human laryngeal squamous cell carcinoma and K-ras gene point mutations. Methods: The expression of K-ras in human laryngeal squamous cell carcinoma cell lines (Hep-2) and human pancreatic carcinoma cell lines (MIAPaCa-2) was detected by using RT-PCR. Results: The expression of K-ras mRNA in Hep-2 and MIAPaCa-2 was strong and positive. Conclusion: The expression of K-ras mRNA in human laryngeal squamous cell carcinoma cell lines (Hep-2) is positive. Development of laryngeal carcinoma might be related to the activation of K-ras gene point mutation.

关 键 词:K-RAS human laryngeal squamous cell carcinoma cell lines (Hep-2) RT-PCR 

分 类 号:R739.65[医药卫生—肿瘤]

 

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