人肌无力症骨骼肌纤维的超微病理改变  

Ultrapathological changes of skeletal myofiber in human amyosthenia

作　　者：刘贵生[1] 李双庆 薛平[1] 马洪骏[1] 雷建章[1] 

机构地区：[1]河北医科大学电镜实验中心,河北石家庄050017 [2]武警8645部队医院,河北石家庄050000

出　　处：《电子显微学报》2006年第1期45-47,共3页Journal of Chinese Electron Microscopy Society

摘　　要：为研究肌无力症患者骨骼肌纤维的超微病理变化,采用超薄切片透射电镜观察分析法。电镜下可见到肌纤维局部肌节变形、粗细肌丝紊乱、明暗带不清、Z盘模糊、三联体减少、线粒体残损空泡化、糖原颗粒沉积、脂褐素增多以及肌纤维间质液化。骨骼肌原纤维及细胞器超微结构改变对肌无力超微病理诊断有重要意义。To study the ultrapothological changes of skeletal myofibril in human myoasthenia. Ultrathin sections of peroneal muscle from 20 cases of amyosthenia were observed under the transmission electron microscope. Some areas of the peroneal muscle fiber showed the changes as follows; 1 ）Deformation of sareomere;2）Disordered and intersected thin and thick myofilaments; 3）Undiscernible I and A band; 4）Blurred Z disc;5） Decrease in number of the triad of muscle fibers; 6）Vacuolation and lamellar structure formation in the mitochondria; 7）Abnormal deposition glycogen granules;8） Increase in number and size of lipofuscin granules;9）Liquefaction of the intercellular substance,etc. The ultrastructural changes of skeletal muscle myofibril possess an important significance for the pathological diagnosis of human myoasthenia.

关 键 词：肌无力症 骨骼肌纤维 肌细胞器 超微病理 

分 类 号：R361[医药卫生—病理学]