促甲状腺激素释放激素在应激性溃疡致病过程中的作用  

Role of thyrotropin-releasing hormone in formation of stress ulcer

作　　者：郭益民[1] 李旭[1] 陈然[1] 夏钦贵[1] 

机构地区：[1]温州医学院生理学教研室,浙江省温州市325035

出　　处：《世界华人消化杂志》2006年第2期216-219,共4页World Chinese Journal of Digestology

基　　金：温州市科学技术委员会基金资助项目;No.00010

摘　　要：目的:探讨促甲状腺激素释放激素(TRH)在冷束缚应激性溃疡发病中的作用及其机制．方法:选用SD大鼠制备应激性溃疡模型,观察侧脑室注射TRH或TRH抗血清后对胃黏膜、胃液的分泌量和胃运动的影响．结果:侧脑室注射TRH 3h后,可使室温条件下禁食24h的清醒大鼠胃黏膜严重损伤,胃液量(5．5±0．7 mL/2 h vs 2．7±0．6 mL/2h, P<0．01)和总酸排出量(539．4±50．5μmol HCl/2h vs 317．7±45.3 μmol HCl/2 h,P<0．05) 均比对照组明显增加,胃壁结合黏液的分泌减少(1．35±0．08 vs 2．21±0．11,P<0．01),胃收缩频率(1．2±0.2 vs 0．4±0．1,P<0．01)、收缩波宽度(17．2±2．0 vs 8．1±1．1,P<0．01)和每分胃运动指数(90．3±14．2 vs 13．2±3．1,P<0．01)均明显高于对照组,冷束缚应激引起的大鼠胃黏膜损伤作用能被侧脑室注射TRH抗血清明显抑制(溃疡指数:10．2±3．9 vs 30．3±5．5,P<0．01)．结论:侧脑室注射TRH可使胃黏膜产生与应激相类似的溃疡,脑内TRH合成分泌增多是冷束缚应激时胃黏膜损伤的重要原因．AIM： To investigate the role of thyrotropin-releasing hormone （TRH） in the rat ulcer induced by cold-restraint stress and its possible mechanism. METHODS： The rat model of stress ulcer was constructed by cold-restraint method. The changes of gastric mucosa, gastric juice secretion, and gastric motility were evaluated after injection of TRH or TRH antiserum into the lateral ventricle. RESULTS： Three hours after the administration of TRH, severe damages were observed in the gastric mucosa of rats fasting for 24 h at room temperature. As compared with the control group, the volume of gastric juice secretion （5.5 ± 0.7 mL/2 h vs 2.7 ± 0.6 mL/2 h, P 〈 0.01） and total acid output （539.4 ± 50.5 μmol HCl/2 h vs 317.7 ± 45.3 μmol HCl/2 h, P 〈 0.05） were increased markedly. Gastric wall mucus secretion was decreased （1.35 ± 0.08 vs 2.21 ± 0.11, P 〈 0.01）, while the frequency of gastric contraction （11 ± 0.2 vs 0.4 ± 0.1, P 〈 0.01）, the width of contractive wave （17.2 ± 2.0 vs 8.1 ± 1.1, P 〈 0.01）, and the motility index per minute （90.3 ± 14.2 vs 13.2 ± 3.1, P 〈 0.01） were elevated significantly. The administration of TRH antiserum significantly inhibited the gastric mucosa damage caused by cold restraint stress （ulcer index： 10.2 ± 3.9 vs 30.3 ± 5.5, P 〈 0.01）. CONCLUSION： The injection of TRH into the lateral ventricle can induce gastric mucosal ulcer, which is similar to the stress ulcer. The enhancement of TRH synthesis in the brain plays a crucial role in the gastric mucosal damage induced by cold-restraint stress.

关 键 词：促甲状脓激素释放激素 应激性溃疡 侧脑室 

分 类 号：R573.1[医药卫生—消化系统]