感冒药YL2000水煎剂中挥发性成分的GC-MS分析  

Analysis of the volatile components of YL2000 decoction by GC-MS

作　　者：张晓娜[1] 陈龙[1] 邢东明[1] 杜力军[1] 丁怡[1] 王伟[1] 

机构地区：[1]清华大学生物科学与技术系,北京100084

出　　处：《中国中药杂志》2006年第4期298-300,共3页China Journal of Chinese Materia Medica

摘　　要：目的:研究感冒药YL2000水煎剂中挥发性成分,并考察其中含挥发油的羌活、独活、黄芩、黄连4味中药配伍后对各单味中药挥发油成分的影响。方法:水蒸气蒸馏法提取YL2000水煎剂的挥发性化学成分,气相色谱-质谱法分离并分析鉴定其成分,用峰面积归一化法测定其相对含量,并与文献中报道的各单味中药挥发油成分进行比较。结果:从挥发油中分离出146种化合物,初步鉴定了其中39个化合物,其挥发性成分总量占色谱峰总面积的85.66%。大部分单味中药中挥发油含量较高的成分在YL2000共煎液中未能检测到,多数成分存在于共煎液挥发油中而在单味药挥发油中无任何相关文献报道。结论:YL2000组成中药配伍对挥发油成分的变化提示,在煎煮过程中发生了增溶作用,可能存在一定的化学反应以及挥发性的成分蒸发了,导致部分成分发生改变。Objective： To analyze the volatile components of YL2000 decoction, which contain four herbs：rhizome and root of the No- topterygium incisum, the mot of the Angelica pubescens f. biserrata, ScuteUaria baicalensis and Coptis chinensis and investigate the changes of volatile constituents from those four herbs before and after compatibility of the herbal medicines. Method： The volatile components of YI.2000 decoction were extracted by water-steam distillation, separated and identified by GC-MS. The relative percent content of each volatile component was quantified by area normalization method. The volatile components of YL2000 decoction were compared with the composition of the volatile oil from individual herb respectively. Result： 39 of the 146 separated constituents in volatile oil of YL2000 decoction, accounting for 85.66 %, were identified and quantified. After compatibility of the herbal medicines, most volatile oil components reported by high proportion in individual herb were not detected, in the mean time, some components in volatile oil of YL2000 decoction have never been reported before in those of all four herbs. Conclusion： The changes of volatile oil from those four herbs before and after compatibility of the herbal medicines indicate that solubilization, chemical reactions and evaporation of some volatile components during decocting may induce changes of several components.

关 键 词：羌活 独活 黄芩 黄连 配伍 挥发油 气相色谱-质谱 

分 类 号：R284[医药卫生—中药学]