油酸所致犬ARDS中酸碱平衡及电解质变化的研究  

Study on change of the acid-base balance and electrolyte in dogs with ARDS caused by oleic acid

作　　者：杜永洪[1] 王导新[2] 陈文直[2] 黎克全[2] 胡凯[1] 王智彪[1] 

机构地区：[1]重庆医科大学生物医学工程系医学超声工程研究所,重庆400016 [2]重庆医科大学第二临床学院,重庆400010

出　　处：《中国急救医学》2006年第3期193-194,共2页Chinese Journal of Critical Care Medicine

基　　金：国家教育部创新团队发展计划(教技函[2005]);重庆市自然科学基金项目资助(渝科发计字[2003]20号)

摘　　要：目的探讨用油酸建立Beagle犬急性呼吸窘迫综合征(ARDS)模型对酸碱平衡和电解质的影响。方法25只Beagle犬通过颈静脉注射油酸,建立ARDS动物模型,连续检测动脉血中PaCO2和PaO2的变化,静脉血中K+、Na+、Cl-和Ca2+的变化。根据检测结果,通过呼吸机通气治疗和静脉补充电解质,纠正Beagle犬实验过程中电解质紊乱和酸碱平衡失调。结果与基础值相比,颈静脉泵入油酸后的10 h内:①PaO2和PaCO2均降低,表现为代谢性酸中毒。②血钙、血钾呈进行性下降,达到ARDS诊断标准时,Beagle犬血中Ca2+为1.17±1.20 mmol/L、K+为4.54±0.58 mmol/L。结论用油酸建立Beagle犬ARDS模型可导致酸碱平衡失调和电解质紊乱。通过呼吸机通气治疗和静脉补充电解质,可有效纠正实验过程中出现的酸碱平衡失调和电解质紊乱。Objective To explore the iafluence of oleic-acid-induced ARDS in Beagle dogs on the acid-base balance and electrolyte. Method 25 Beagle dogs were injected oleic acid through jugular vein to establish ARDS animal model. The variations of PaCO2 and PaO2 in arterial blood and the K^＋ , Na^＋ , Cl^- and Ca^2＋ of venous blood were continuously monitored. According to the testing results, mechanical ventilation treatment and IV electrolyte Complement were used to rectify the electrolyte disorder and maladjustment of acid-base balance. Results Comparing with fundamental values, in 10 hours after injection of oleic acid through jugular vein, those values of Pa^O2 and PaCO^2 both decreased, presenting metabolic acidosis. And those of K^＋ and Na^＋ in the blood decreased progressively. When reaching the diagnosiscritefia of ARDS, Ca^2＋ in the Beagle dogs was 1.17±1.20 mmol/L and K^＋ was 4.54±0.58 mmol/L. Conclusions Establishment of ARDS in Beagle dogs using oleic acid may lead to acid-base balance and electrolyte disorder, but these may be rectified after mechanical ventilation treatment and IV electrolyte complement.

关 键 词：油酸 呼吸窘迫综合征 酸碱平衡 电解质 BEAGLE犬 

分 类 号：R363[医药卫生—病理学]