β-内酰胺类抗生素酶促合成新进展  

New Progress in Enzymatic Semi-Synthesis of β-Lactam Antibiotics

作　　者：吴伟波[1] 王旭[2] 王娜[1] 吴起[1] 林贤福[1] 

机构地区：[1]浙江大学化学系,杭州310027 [2]浙江工业大学化工与材料学院,杭州310032

出　　处：《有机化学》2006年第3期292-298,共7页Chinese Journal of Organic Chemistry

摘　　要：β-内酰胺类抗生素的合成在制药工业中占据重要的地位,相关的酶促合成方法研究备受关注;酶促合成显著提高合成效率,减少三废的排放,是实现绿色合成的有效方法.综述了近年来β-内酰胺类抗生素酶促合成研究的新进展,包括一锅合成法、原位产物排出法、介质技术和酶固定化方法.Semi-synthetic β-lactam antibiotics plays a significant role in pharmaceutical industry. Enzymatic synthesis of β-lactam antibiotics provides an effective green technology, which could decline the generation of waste and the cost of production remarkably. This review focuses on the recent progresses of enzymatic semi-synthesis of β-lactam antibiotics, mainly including one-pot synthesis, in situ product removal, media techniques and immobilization techniques of enzyme.

关 键 词：Β-内酰胺类抗生素 青霉素 头孢菌素 酶促合成 绿色工艺 

分 类 号：TQ465[化学工程—制药化工]