吸烟对脑梗死患者血清可溶性细胞间黏附分子-1水平变化的影响及其意义  

Effect and significance of cigarette smoking on level of serum sICAM-1 in cerebral infarction patients

作　　者：孙素梅[1] 耿建红[1] 柳忠兰[2] 

机构地区：[1]中国医科大学第一临床学院,辽宁沈阳110005 [2]中国医科大学第一临床学院神经内科,辽宁沈阳110001

出　　处：《中国现代医学杂志》2006年第5期709-711,715,共4页China Journal of Modern Medicine

基　　金：卫生部科学研究基金;辽宁省自然科学基金(9810500303)资助项目(98-1-196)

摘　　要：目的研究吸烟对健康人群和脑梗死患者血清sICAM-1水平的影响,探讨吸烟在脑梗死发生发展中的作用。方法采用双抗体夹心ELISA法测定31例脑梗死吸烟者和31例脑梗死不吸烟者,26健康吸烟者和28例健康不吸烟者血清sICAM-1水平。结果脑梗死吸烟组(280.22±35.93)和健康吸烟人群(203.31±50.91)sICAM-1水平高于脑梗死不吸烟组(237.48±55.42)和健康不吸烟人群(162.42±64.65)(P<0.05);血清sICAM-1水平升高与吸烟指数呈正相关(r=0.428,P<0.01)。结论吸烟导致血清sICAM-1水平升高,参与并加重了脑梗死的发生发展过程。[ Objective] To study the role of cigarette smoking during the process of the process of the occurrence and development of cerebral infarction by observing the changes of serum sICAM-1 concentration among healthy smokers, cerebral infarction patients. [Methods] The level of serum slCAM-1 was measured by two-layer antibody sandwich enzyme-linked immunosorbent assay ELISA in 31 cases of smokers with cerebral infarction and 31 cases of no-smokers with cerebral infarction, 26 healthy smokers and 28 healthy no-smokers. [Results] The level of serum sICAM-1 in cases of smokers with cerebral infarction and healthy smokers were higher than that of nonsmokers with cerebral infarction and heahhy no-smokers （P 〈0.05, respectively）. The level of serum sICAM-1 was well correlated with smoking index （r =0.428, P 〈0.01）. [Conclusion] Cigarette smoking can improve the level of serum sICAM-1, involve and aggravate the process of the occunrrnce and developmrnt of cerebral infarction.

关 键 词：吸烟 可溶性细胞间黏附分子-1 脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学]