脾气虚、肝郁脾虚及胃实热证患者阿魏酸药代动力学特征比较  

Pharmacokinetic characteristics of ferulic acid in patients with different syndromes of deficiency of spleen qi, stagnation of liver qi and spleen deficiency, and excess of stomach heat

作　　者：任平[1] 黄熙[2] 李双庆[1] 许树耘[3] 万美华[2] 周亚雄[3] 周毅武[3] 唐文富[2] 

机构地区：[1]四川大学华西医院全科病房,成都610041 [2]四川大学华西医院中西医结合科,成都610041 [3]四川大学华西医院急诊科,成都610041

出　　处：《中西医结合学报》2006年第2期147-151,共5页Journal of Chinese Integrative Medicine

基　　金：国家自然科学基金杰出青年基金资助项目(No.30325045);国家自然科学基金面上项目(No.30271648)

摘　　要：目的:应用药代动力学(pharmacokinetics,PK)方法研究中医证本质,探讨脾气虚、肝郁脾虚及胃实热证患者体内阿魏酸(ferulicacid,FA)的PK特征。方法:选择21例健康自愿者、20例肝郁脾虚证患者、22例脾气虚证患者和19例胃实热证患者,予以口服自拟加味逍遥散后,采用高效液相色谱法观察血清FA的PK参数。结果:与健康自愿者比较,脾虚证患者的吸收速度常数和消除速度常数均下降,表观一级吸收速率常数升高;肝郁脾虚证患者的吸收速度常数、消除速度常数和表观一级吸收速率常数均下降;胃实热证患者的消除速度常数和表观一级吸收速率常数均升高;差异有统计学意义。结论:脾气虚证患者PK特征表现为吸收速度加快,分布和排泄减慢;肝郁脾虚证患者PK特征表现为吸收、分布和排泄均减慢;胃实热证患者PK特征表现为吸收和排泄加快。提示三种中医证型患者的PK特征存在差异。Objective： To investigate the nature of syndrome of traditional Chinese medicine by means of pharmacokinetic （PK） method, Methods： Twenty-one healthy volunteers, 20 patients with syndrome of stagnation of liver qi and spleen deficiency, 22 patients with syndrome of deficiency of spleen qi and 19 patients with syndrome of excess of stomach heat were included and administered to take Jiawei Xiaoyaosan Recipe （JWXYSR）. The serum PK parameters of ferulic acid （FA） were examined by high performance liquid chro- matography （HPLC） method. Results： The absorption rate constant （α） and the elimination rate constant （β） were both decreased while the apparent first-order absorption constant （Ka） was enhanced significantly in the patients with syndrome of deficiency of spleen qi; the α, β and Ka were all reduced in the patients with syndrome of stagnation of liver qi and spleen deficiency; the β and Ka were increased in the patients with syndrome of excess of stomach heat, as compared with the corresponding PK parameters in the healthy volunteers （P〈0.01）, Conclusion： The PK analysis of FA in the patients with syndrome of deficiency of spleen qi shows that the absorption rate is accelerated, and both the distribution and elimination rates are slowed down. The absorption, distribution and elimination rates of AF are all slowed down in the patients with syndrome of stagnation of liver-qi and spleen deficiency, while the absorption and elimination rates of AF are both accelerated in the patients with syndrome of excess of stomach heat. There are obvious differences in the PK characteristics among these three syndromes.

关 键 词：脾虚证 肝郁脾虚证 胃实热证 阿魏酸 药代动力学 

分 类 号：R256.3[医药卫生—中医内科学]