肝癌高发区不同饮用水类型中微囊藻毒素含量调查  

StudiesonMicrocystinContentsinDifferentDrinkingWaterinHighlyEndemicAreaofLiverCancer

作　　者：陈刚[1,2,3,4] 俞顺章[1,2,3,4] 卫国荣[1,2,3,4] 陈公超[1,2,3,4] 徐小英[1,2,3,4] 黄裕华[1,2,3,4] Ken-ichi Harada Yoshio Ueno 

机构地区：[1]上海医科大学流行病学教研室 [2]江苏省海门市卫生防疫站 [3]日本名城大学 [4]日本东京理科大学

出　　处：《中华预防医学杂志》1996年第1期6-9,共4页Chinese Journal of Preventive Medicine

摘　　要：为了解肝脏促癌剂微囊藻毒素（ＭＣ）在肝癌高发区饮用水中的污染情况，于１９９２至１９９３年对江苏海门居民饮用水中藻类及其产生的ＭＣ进行了检测，经鉴定在海门沟河水中颤藻是目前已被证明能产生ＭＣ的最常见的藻属；在６５个水样中有２份经高效液相和液相色谱／质谱分析确定含有ＭＣ。进一步于１９９４年７月在江苏海门采集不同饮用水源共９８９份，采用高敏感度酶联免疫方法测定ＭＣ含量。结果在沟塘水、河水、浅井水和深井水中ＭＣ的阳性率（＞５０ｐｇ／ｍｌ）分别为１７．３％，３１．９％，４．３％，０．０％；阳性样本中ＭＣ平均含量分别为１０１，１６０，６８，０。在沟塘水和河水中ＭＣ的阳性率和阳性样本中的平均含量均显著大于浅井水和深井水，提示应对饮用水中ＭＣ与肝癌的关系作进一步研究。Inordertostudythepolutionwithmicrocystin(MC),apotentlivercancerpromoter,indrinkingwatreinhighlyendemicareaoflivercancer,cyanobacteriaanditsproductMCwerede-tectedindrinkingwaterinHaimen,JiangsuProvinceduring1992to1993.Oscilatoriawasidentifiedasthemostcommonspeciesofcyanobacteriainpond-ditchandriverwaterinHaimen,JiangsuProvince,whichcanproduceMC.MCwasdetectedintwoof65watersampleswithhighperfor-manceliquidchromatography,liquidchromatographyandmassspectrography.Inaddition,studieswereconductedin989sampescolectedfromdrinkingwaterinHaimen,JiangsuProvinceandmoresensitiveELISAwasusedtodetecttheirMCcontents.ResultsshowedproportionsofsampleswithpositiveMC(greaterthan50pg/ml)were17.3%,31.9%,4.3%and0forpond-ditch,river,shal-lowanddeepwelwater,respectively,withaveragecontentsof101,160,68and0pg/ml,respec-tively.proportionsofpositiveMCsamplesandaverageMCcontentsforpond-ditchwaterweresig-nificantlygreaterthanthoseinshalowanddeepwelwater.Itsuggestsstudiesonrelationshipbe-tweenMCandlivercancershouldbeconductedfurther.

关 键 词：肝肿瘤 饮水 微囊藻毒素 

分 类 号：R735.701[医药卫生—肿瘤]