晚期非小细胞肺癌的预后因子分析  

Prognosis factors analysis of nonsmall-cell lung cancer in advanced stage

作　　者：张淑香[1] 

机构地区：[1]河南中医学院第一附属医院,河南郑州450000

出　　处：《现代中西医结合杂志》2006年第6期705-707,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的分析晚期非小细胞肺癌(NSCLC)预后相关因子,以判断病情、指导治疗。方法将107例NSCLC患者按中医辨证分型分为5型,部分患者采用中医药方法治疗,部分患者采用中西医结合方法治疗。采用卡卜兰-迈尔(Kaplan-Meier)方法进行生存分析,采用Cox回归分析进行晚期NSCLC的预后分析。结果5种中医分型的生存时间气虚痰湿型>气滞血瘀型>阴虚毒热型>气阴两虚型>热毒炽盛型,各中医证型的生存率相比较均具有显著性差异(P均<0.01)。中西医结合治疗比纯中医药治疗疗效好(P<0.05)。结论晚期NSCLC预后保护因子有治疗方法、CD4+、CD4+/CD8+、卡氏评分、辨证分型、疗程,预后危险因子有原发病灶、年龄、吸烟、CD8+、恶性胸水、上腔静脉综合征、脑转移、骨转移、临床分期、病理类型、TPA、CEA、CA125。Objective It is to analyze the prognosis correlated factors of nonsmallcell lung cancer （NCSLC） in advanced stage so to diagnose the disease and guide tre-atment. Methods 107 patients with NCSLC were divided into five types of syndromes according to differential diagnosis typing. Some patients were treated with traditional Chinese medicine and some were treated with methods of integrated traditional Chinese and western medicine. Existence analysis was done with Kaplan- Meier method and prognosis analysis of NCSLC in advanced stage was done with Cox regression statistical method. Results Five syndromes survival time from long to short in sequence was Qi- deficiency plus phlegm and wetness syndrome 〉 Qi stagnancy and blood stasis syndrome 〉 Yin - dificiency plus toxic heat syndrome 〉 Qi Yin deficiency syndrome〉 pyretic toxicity fervidity syndrome. There were significant difference in survival rate among five syndromes （P〈 0.01 ）. The curative effect of integrated traditional Chinese and western medicine was better than simple traditional Chinese medicine （P〈0.05）. Conclusion The prognosis protective factors of NSCLC in advanced stage were treatment method, CD4^＋ , CD4^＋/CD8^＋, Kamofsy marks, differential diagnosis typing and treatment course, and the dangerous prognosis factors were primary focus, age, smoking, CD8 ^＋ , malignant pleural effusion, superior vena cava syndrome, brain metastasis, bone metastasis, clinical stage, pathology tape, TPA, CEA and CA125.

关 键 词：非小细胞肺癌 晚期预后因子 危险因子 保护因子 

分 类 号：R734.2[医药卫生—肿瘤]