贝复济在乳腺癌术后皮瓣坏死中的应用  

bFGF for skin flap necrosis in patients suffering breast cancer and undergoing mastectomy

作　　者：赵强[1] 

机构地区：[1]雅安市人民医院普外科,四川雅安625000

出　　处：《西部医学》2006年第2期182-183,共2页Medical Journal of West China

摘　　要：目的评价贝复济治疗乳腺癌术后皮瓣坏死的效果。方法将61例乳腺癌术后皮瓣坏死患者随机分为治疗组31例和对照组30例,分别应用贝复济和生理盐水喷撒和湿敷创面,观察两组皮损的愈合情况。结果治疗组和对照组的皮损总面积分别为277和268cm2,平均愈合时间分别为16和25天,平均每日愈合面积分别为0.56和0.31cm2(P<0.01)。结论贝复济能够促进皮损创面愈合,为乳腺癌术后尽快施行化疗和放疗赢得了宝贵时间。Objective To evaluate the efficacy of basic fibroblast growth factor （bFGF） for the healing of skin flap necrosis after mastectomy. Methods Among 61 breast cancer patients undergoing mastectomy with skin flap necrosis, 31 were treated by bFGF, and 30 patients served as control, bFGF was sprayed and compressed on the site of the wound. Results The total necrosis area for treatment and control groups was 277 cm^2, and 268 cm^2, respectively. The average wound-healing time for treatment and control groups was 16 days and 25 days, respectively. The average wound-healing rates were 0. 56 cm^2/day and 0, 31 cm^2/day, respectively （P〈0. 01）. Conclusion bFGF has been approved to shorten the healing time of skin flap necrosis in patients undergoing mastectomy, which will potentially facilitate undergoing chemotherapy and radiotherapy for these patients soon after mastectomy.

关 键 词：乳腺肿瘤 碱性成纤维细胞生长因子 伤口愈合 

分 类 号：R737.9[医药卫生—肿瘤]