OX-LDL对THP-1细胞脂蛋白受体基因表达的影响  

The Effects of OX-LDL on Lipoprotein Receptors Gene Expression of THP-1 Cells

作　　者：范乐明[1] 姜传仓 朱宇[1] 蔡海江[1] 

机构地区：[1]南京医科大学动脉粥样硬化研究中心,南京210029

出　　处：《南京医科大学学报（自然科学版）》1996年第1期17-20,共4页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：以 THP-1细胞为模型,观察 OX-LDL 对其脂蛋白受体的影响。结果发现,在 PMA 诱导基础上,OX-LDL 使 THP-1细胞的 LDL 受体与清道夫受体活性进一步向相反方向变化。其原因可能在于,OX-LDL 在基因转录水平对这两种受体基因的表达发生相反方向的凋控作用。对其中 OX-LDL 与清道夫受体之间正反馈调节的意义及可能机制进行了讨论。The effects of ox-LDL on lipoprotein receptors were observed with THP-1 cells as the cell model.The results showed that after induction with PMA,the LDL receptor and scavenger recep- tor activities of THP-1 cells further changed in the opposite direction by addition of ox-LDL to these cells.The reason accounting for such changes may be that ox-LDL could up and down-regulate the gene expression of these receptors respectively at the transcription level.The significance and the possi- ble mechanisms of such positive feed-back between ox-LDL and scavenger receptor were discussed.

关 键 词：动脉壁 巨噬细胞 低密度 脂蛋白 受体 基因表达 

分 类 号：R394－33[医药卫生—医学遗传学] Q344.13[医药卫生—基础医学]