罗望子胶的毒性和致突变研究  

A Study on the Toxicity and Mutagenicity of Tamarindus Indica Linn Gum

作　　者：赵岩[1] 钟才云[1] 谢慧文[1] 张志新[1] 汪建平[1] 

机构地区：[1]南京医科大学营养与食品卫生学教研室,南京210029

出　　处：《南京医科大学学报（自然科学版）》1996年第1期60-61,71,共3页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：测定罗望子胶的急性毒性,并选用3种体内和体外的短期测试系统,对其致突变进行试验。实验结果表明,罗望子胶对雌,雄性大鼠、小鼠经口 LD_(50)分别为9 260 mg/kg 和大于10 000mg/kg,属于实际无毒。在 Ames 试验中。未呈现致突变性。在体内试验中,未引起小鼠骨髓嗜多染红细胞微核率和小鼠精子畸变率的增加,在3项致变试验中,罗望子胶未呈现致突变活性。Using three internal and external short-term system the oral acute toxicity and muta genicity for Tamarindus indica linn gum was measured in this study.The results showed that the medi- an lethal dose(LD_(50))was 9260 mg/kg to rats,more than 10000 mg/kg to mice,which indicated that Tamarindus indica linn gum is classified as a practical non-toxic substance.The mutagenic assay, including Ames test,micronucleus assay and the aberration rate of sperm in mice did not show any pos- itive results.

关 键 词：罗望子胶 毒性试验 致突变性 

分 类 号：R994.4[医药卫生—毒理学] TS202[医药卫生—药学]