肿瘤微循环的新形式——血管生成拟态  

Vasculogenic mimicry: the new form of tumorous microcirculation

作　　者：苏敏[1] 尧良清[1] 丰有吉[1] 金惠铭[2] 

机构地区：[1]复旦大学附属妇产科医院,上海200011 [2]复旦大学上海医学院生理与病理生理学系,上海200032

出　　处：《国际病理科学与临床杂志》2006年第1期11-13,17,共4页Journal of International Pathology and Clinical Medicine

基　　金：国家自然科学基金(30471806);中国博士后科学基金(20040350454);上海市科学技术委员会科研计划基金(04JC14021);上海市医学重点学科建设项目(05016)

摘　　要：血管生成拟态是在少数高度恶性肿瘤中新发现的一种血管生成方式,使得肿瘤极易侵袭和转移,其特征是管腔由癌细胞覆盖。血管生成拟态的发生与肿瘤细胞胚胎样特性、基质蛋白、金属基质蛋白酶等表达有关,血管生成拟态应与纤维血管隔、肿瘤内微出血等区别。Vasculogenic mimicry, a term that describes a novel pattem of vasculafization in a few highly aggressive tumors, may contribute to high invasiveness and metastasis of tumor cells. It is characterized by the tumor cell-lined vascular channels. The presence of vasculogenic mimicry is associated with embryonic-like ability of tumor cells, matrix protein, the expression of matrix metalloproteinases, and so on. Vasculogenic mimicry should be distinguished from fibrovascular septa, and intratumoral microhemorrhage.

关 键 词：肿瘤 血管生成拟态 微循环 

分 类 号：R730.2[医药卫生—肿瘤]