绒毛膜癌的组织病理学研究——癌细胞β-HCG测定及动力形态学观察  

CHORIOCARCINOMA: CELL β-HCG LEVEL AND KINETOMORPHOLOGY

作　　者：熊世钢[1] 姚敏[1] 王萍[1] 

机构地区：[1]蚌埠医学院病理学教研室

出　　处：《蚌埠医学院学报》1990年第1期16-19,共4页Journal of Bengbu Medical College

摘　　要：本文用免疫组化和图象分析法,对子宫绒癌51例进行随访观察。发现有下列情况者其预后良好:1.合体滋养细胞(ST)内β-HCG含量高;2.癌细胞以ST为主;3.ST和细胞滋养细胞发育同步;4.癌细胞浆和核发育平行;5.癌细胞呈丛状生长;6,癌巢境界基本清楚;7.癌巢周围间隙宽;8.癌细胞摸拟胎盘绒毛排列;9.肿瘤侵犯子宫壁较表浅。文中还对上述指标间的关系进行了讨论。本结果提示,免疫组化、定量分析法及形态学的动态观察对绒癌研究具有重要意义。An immunohistochemical and image-analytical study of 51 pathologically-proved uterine choriocarcinomas was conducted. Three to eight tissue blocks were taken from each uterine specimen for pathological section. The slides were stained with HE and PAP ( Sternberger). The intracellular contents of @-HCG was determined with an microscopic analyzer ( Leitz MPV-Taplus). A mong twenty-seven items studied, the following 9 items were found to be associated with a good prognosis for the patients: 1)a higher level of @-HCG in syncytiotro-phoblast ( ST ) ; 2) a predominance of ST; 3 ) the synchronous development of plasms and nuclei; 4 ) synchronous development of ST and cytotrophoblast; 5)a regular arrangement of tumor cells; 6) a plexiform of nidi; 7 ) well-defined nidi; 8) a broad surrounding space between the nidi and the host tissue; and 9)a superficial invasion of the tumor cells into the uterine wall. Relationship between the above-mentioned items and the prognosis are disscused. The results suggest that the immunohistochemical examination and image-analysis of the lesion may be helpful in evaluating the prognosis.

关 键 词：绒毛膜癌 组织病理学 Β-HCG 

分 类 号：R737.330.2[医药卫生—肿瘤]