滋养细胞肿瘤β—HCG计量学研究  

A QUANTITATIVE STUDY OF β-HCG IN TROPHOBLASTIC TUMORS

作　　者：张世馥[1] 谢群[1] 姚敏[1] 王萍[1] 熊世钢[1] 刘森桂[2] 

机构地区：[1]蚌埠医学院病理学教研室 [2]蚌埠医学院卫生学教研室

出　　处：《蚌埠医学院学报》1990年第1期6-9,共4页Journal of Bengbu Medical College

摘　　要：本文应用显微图象分析和免疫组化法定量测定52例绒癌、49例侵蚀性葡萄胎、30例葡萄胎和15例正常绒毛的ST及CT内B-HCG含量。发现(1)以ST增生为主型患者的病死率低于以CT为主型(P<0.005)。(2)绒癌两种滋养细胞的β-HCG含量高于侵蚀性葡萄胎、葡萄胎和正常绒毛(P<0.001)。(3)侵蚀性葡萄胎增生型的β-HCG含量高于退变型(P<0.002)。(4)绒癌和侵蚀性葡萄胎中,滋养细胞内β-HCG含量与其滋养细胞增生程度呈正相关。(5)葡萄胎和正常绒毛的两种滋养细胞β-HCG量基本相同(P>0.05)。滋养细胞内β-UCG量的变化反映了肿瘤灶内存活的瘤细胞数量、滋养细胞的增生能力及其增生程度。因此可借此以判断治疗效果及患者的预后。Microspectroscopic measurement of the β-HCG content of trophoblastic cells were made in 52 choriocarcinomas, 49 invasive moles, 30 hydatidi-form moles, and 15 normal placental tissues. The principal findings were the following. (1) The mortality of patients with the syncytiotrophoblast-predominant type was lower than that of the cytotro-phoblast-predominant type. ( 2 ) The β-HCG content of trophoblasts of choriocarcinoma was higher than that of the invasive moles and normal placental tissues ( P<0.001 ). ( 3 ) In invasive mole, the degenerative type had lower β-HCG content as compared with the proliferative type ( P<0. 002 ) . ( 4 ) The β-HCG content of trophoblast in choriocarcinoma and invasive mole was positively correlated with the degree of trophoblastic proliferation. ( 5 ) Hydatidiform mole was similar to normal placental tissues in the β-HCG content ( P>0.05 ). The chang of β-HCG content of trophoblasts reflected the number of surviving cells, their proliferative ability and the degree of proliferation of the trophoblast. This might serve as a useful parameter in predicting the effectness of treatment and the probable outcome of the disease.

关 键 词：滋养细胞肿瘤 Β-HCG 计量学 

分 类 号：R737.330.2[医药卫生—肿瘤]