侵蚀性葡萄胎的组织病理学及β-HCG计量学研究  

HISTOPATHOLOGIC AND β-HCG QUANTITATIVE ANALYSIS OF INVASIVE MOLE

作　　者：张世馥[1] 谢群[1] 姚敏[1] 王萍[2] 熊世钢[1] 刘森桂[3] 

机构地区：[1]蚌埠医学院病理学教研室 [2]蚌埠医学院院病理学教研室 [3]蚌埠医学院卫生学教研室

出　　处：《蚌埠医学院学报》1990年第1期3-6,共4页Journal of Bengbu Medical College

摘　　要：本文研究了49例侵蚀性葡萄胎的组织病理学和β-HCG含量。根据滋养细胞增生程度,将其分为退变型和增生型。后者进一步分为轻度、中度和重度增生。7例退变型随访5～11年无1例死亡。42例增生型中,4例在术后2年内死亡。 研究发现侵蚀性葡萄胎以合体滋养细胞为主者较以细胞滋养细胞为主者预后好(P<0.005),而β-HCG含量仅与侵蚀性葡萄胎的分型(P<0.002)和滋养细胞增生程度有关(r分别为0.993和0.990)。Histopathologic and β- HCG content of trophoblast in 49 cases of invasive mole has been studied with micro-spectroscopic image analysis. On the basis of the degrees of proliferation of trophoblast, the invasive mole was divided into degenerative and proliferative types.The latter was further divided into mild, moderate, and marked proliferation. In 7 cases of the degenerative type, no deaths occurred during a follow-up period of 5-11 years. Of the 42 proliferative types, 4 patients died less than 2 years after operation. The patients with the syncytiotrophoblast-predominant type of invasive mole had a better prognosis than those with the cytotrophoblast-predominant type, and β-HCG content of trophoblastic cell in invasive mole had only positive correlation with classification (P<0.002)and with the degree of proliferation of the trophoblasts.

关 键 词：葡萄胎 组织病理学 Β-HCG 计量学 

分 类 号：R737.330.2[医药卫生—肿瘤]