女性首发精神分裂症患者糖调节异常临床研究  

A case-control study on impaired glucose regulation in first-episode female patients with schizophrenia

作　　者：徐乐平[1] 纪菊英[1] 端义扬[1] 孙剑[1] 施辉[1] 邵亚琴[1] 

机构地区：[1]解放军第102医院精神二科,常州213003

出　　处：《中国行为医学科学》2006年第3期247-249,共3页Chinese Journal of Behavioral Medical Science

摘　　要：目的探讨女性首发分裂症患者中糖调节异常(IGR)的发生情况及糖化血红蛋白(HbA1C)用于筛选IGR的可行性。方法首发、未经治疗的女性精神分裂症(180例),及正常对照组(180例),测定空腹血糖(FPG)、糖耐量试验2h血糖值(2HPG),病例组尚测定HbA1C,按WHO标准诊断。结果病例组FPG、2HPG均高于对照组,差异有显著性(P<0.01);患者组诊断IGR38例(21.1%),高于对照组10例(5.6%),差异有显著性(P<0.01);单因素分析、多因素分析均显示,精神分裂症与IGR间存在具有统计学意义的关联(分别OR=4.55、4.64,均P<0.01)。HbA1C对IGR诊断阳性率与金标准比较,差异无显著性(P>0.05)。结论女性首发精神分裂症IGR高发,HbA1C检查可用于IGR筛选。Objective To investigate the prevalence of impaired glucose regulation （IGR） in first-episode female patients with schizophrenia, and primarily assess the possibility of glyeated hemoglobin A1 c （HbA1C ） used for screening IGR. Methods First-episode drug-naive female patients with schizophrenia （ 180 cases） and healthy normal controls （180 cases） were involved in the study. The fasting plasma glucose （FPG） and 2-hour plasma glucose in the oral glucose tolerance test （2HPG） were determined in two groups ,and HbA1 C was determined in case group. The diagnosis of IGR was made according to the WHO criteria. Results FPG and 2HPG were significantly higher in cases than in controls （ P〈 0.01 ）. The prevalence of IGR in cases was significantly higher than in controls（21.1% vs 5.6% , P〈0. 001 ）. With univariable and muhivariable analysis, the schizophrenia showed a significant association with IGR（ OR = 4.55,4.64, both P 〈 0.01 ）. The positive rate of IGR according to HbA1 C was similar as according to gold standard , and no statistically significant difference was found between them（ P〉 0.05）. Conclusion The prevalence of IGR in first-episode female patients with schizophrenia is higher than in controls. HbA1C measuring could be used for screening IGR.

关 键 词：精神分裂症 糖调节异常 

分 类 号：R749.3[医药卫生—神经病学与精神病学]