肝炎后肝硬化ET-1、CGRP、TNF-α和IL-8联合检测的临床意义  

CLINICAL SIGNIFICANCE OF ENDOTHELIN-1,CALCITION GENE RELATED PEPTIDE, ALPHA TUMOR NECROSIS FACTOR AND INTERLEUKIN-8 IN PATIENTS WITH POSTHEPATITIC CIRRHOSIS

作　　者：申群喜[1] 祝玲玲 苏黎[1] 曾云[1] 朱平安 

机构地区：[1]广东省深圳市第二人民医院,广东深圳518035 [2]广东省深圳市盐田区人民医院

出　　处：《承德医学院学报》2006年第1期17-19,共3页Journal of Chengde Medical University

摘　　要：目的:探讨肝炎后肝硬化血浆活性物质ET-1、CGRP和血清TNFα-、IL-8的临床意义。方法:68例肝炎后肝硬化患者,根据Ch ild-Pugh分级分为A级(23例)、B级(20例)、C级(25例)三组。采用放射免疫(R IA)方法联合检测ET-1、CGRP、TNF-α和IL-8水平,并与30例健康组相对照。结果:肝炎后肝硬化组ET-1、CGRP、TNF-α和IL-8水平较健康组明显升高(均P<0.01),且A、B、C三组中ET-1、CGRP、TNF-α和IL-8水平差异显著(均P<0.01),C级>B级>A级。结论:ET-1、CGRP、TNF-α和IL-8水平是反映肝炎后肝硬化肝脏损害程度,可作为预后判断的重要指标。Objective： To explore the clinical significance of Endothelin-1 （ET-1）, Calcition gene related peptide （CGRP） ,alpha tumor necrosis factor （TNF-α） and interleukin-8 （IL-8） in patients with posthepatitic cirrhosis. Methods： 68 patients with posthepatitic cirrhosis were collected and divided into A, B and C groups according to the Child-Pugh grade. Plasma ET-1 ,CGRP and serum TNF-α,IL-8 were detected by RIA methods and compared with control group（30 samples）. Results： The levels of plasma ET-1 ,CGRP and serum TNF-α,IL-8 were higher in patients with posthepatitic cirrhosis than those in control group（P〈0. 01）. There were significant differences of level of plasma ET-1 ,CGRP and serum TNF-α,IL-8 in the A,B and C group in patients（P〈0. 01）. Conclusion： ET-1 ,CGRP,TNF-α and IL-8 were important indexs which reflected the degree of liver damage and estimated the prognosis in posthepatitic cirrhosis.

关 键 词：肝炎后肝硬化 内皮素-1 降钙素基因相关肽 肿瘤坏死因子 白细胞介素-8 

分 类 号：R575.1[医药卫生—消化系统]