HMG-CoA还原酶的结构和调节  

Structure and Regulation of HMG-CoA Reductase

作　　者：李文全[1] 王子花[1] 申瑞玲[1] 

机构地区：[1]山西农业大学动物科技学院,山西太谷030801

出　　处：《动物医学进展》2006年第2期38-40,共3页Progress In Veterinary Medicine

摘　　要：3-羟基-3-甲基戊二酰辅酶A(3-hy-droxy-3-methylglutaryl coenzyme A,HMG-CoA)还原酶是胆固醇合成的限速酶。该酶的生成除了受到它的底物正向调节和终端产物的反馈调节外,还受各种激素的调节。文章就HMG-CoA还原酶的结构,以及胆固醇、胆汁酸、激素包括胰岛素、胰高血糖素、甲状腺素、糖皮质类激素和雌激素对HMG-CoA还原酶生成的调节进行了概述。3-hydroxy-3-methylgultaryl coenzyme A（HMG-CoA）reductase is generally regarded as catalyzing the rate-limiting step in synthesis of cholesterol. It is regulated by various hormones, substrates and terminal products. This paper focused on HMG-CoA reductase structure and regulation of cholesterol , bile acid , hormones including insulin, glucagons, thyroid , glucocorticoids and estrogen.

关 键 词：HMG-COA还原酶 结构 调节 

分 类 号：S852.23[农业科学—基础兽医学] Q55[农业科学—兽医学]