齿槽外科手术辅助正畸牙移动对骨形成的影响  

Effect of Alveolar Surgery-aided Rapid Orthodontic Tooth Movement on Bone Formation

作　　者：康娜[1] 吕涛[1] 任嫒姝[1] 黄兰[1] 白丁[1] 

机构地区：[1]四川大学华西口腔医学院正畸学教研室,成都610041

出　　处：《四川大学学报（医学版）》2006年第2期254-257,共4页Journal of Sichuan University(Medical Sciences)

基　　金：国家自然科学基金(批准号30100212)资助

摘　　要：目的探讨齿槽外科手术对正畸牙齿移动时骨改建的影响。方法以犬为实验对象,实验侧牙列应用简单的齿槽外科手术辅助牙移动,对照侧牙列应用传统牙移动方法,通过四环素荧光标记及免疫组织化学染色的方法,观察牙齿移动过程中张力侧的骨形成情况。结果在四周主动加力阶段,实验侧实验牙远中移动量(4.31±0.46mm)显著多于对照侧(2.16±0.42mm,P<0.01),而支抗牙近中移动量(0.44±0.07mm)与对照侧(0.46±0.09mm)无明显差异(P>0.05)。自体荧光染色结果显示实验侧移动牙张力侧新形成骨量多于对照侧,骨形成蛋白(BMP)免疫组化染色显示,实验侧BMP-2表达增强现象较对照侧出现早,峰值高,而且持续的时间长。结论齿槽外科手术促进了正畸牙齿移动过程中的骨改建,有加速正畸牙齿移动的趋势。Objective To test the effect of alveolar surgery on orthodontic tooth movement and born remodeling. Methods Alveolar surgery was performed on one side （experimental side） whereas the traditional tooth movement was performed on the other side （control side） of the teeth in ten dogs. The treatments lasted for four weeks. The bone formation was evaluated using the vital bone marker tetracycline and immunohistoehemistry 1, 2, 3, 4 and 8 weeks after the treatments respectively. Results In the total of the four weeks, the distal movement of experimental tooth was much faster （4. 31±0. 46 ram） than control tooth （2. 16±0. 42 mm）, whereas the anchorage lost （0. 44±0. 07 mm） was the same with the control （0. 46±0. 09 mm）. Compared to the control side, the tetracycline labeling lines were wider; the increase of the expression level of BMP-2 appeared earlier, greater and lasted longer in the tension area of the experimental side. Conclusion Alveolar surgery could promote bone remodeling and accelerate the movement of orthodontic teeth.

关 键 词：齿槽外科手术 快速牙移动 荧光标记 骨形成蛋白(BMPs) 

分 类 号：R783.5[医药卫生—口腔医学]