HER-2/neu和nm23蛋白在喉鳞状细胞癌中的表达及与浸润转移的相关性  

Correlation between the expression of HER-2/neu,nm23 protein and local invasion and lymph node metastasis of human LSCC

作　　者：李钦[1] 陈彦林[1] 孔平[1] 明伟[2] 马炎焱[1] 杨兆科[1] 杜英华[1] 张大良[2] 

机构地区：[1]临沂市人民医院耳鼻咽喉科,山东临沂276003 [2]山东大学第二医院耳鼻咽喉科

出　　处：《临床耳鼻咽喉科杂志》2006年第6期259-261,共3页Journal of Clinical Otorhinolaryngology

摘　　要：目的:探讨癌基因HER-2/neu及转移抑制基因nm23在喉鳞状细胞癌(LSCC)中的表达及与局部浸润和淋巴结转移的关系。方法:采用免疫组织化学SP法,检测56例LSCC患者手术切除的癌组织中HER-2/neu及nm23蛋白的表达,并以正常喉黏膜组织做对照。结果:HER-2/neu蛋白阳性表达率与喉癌组织的分化程度无明显相关性(P>0.05),与临床分期和淋巴结转移呈正相关(P<0.05或P<0.01);nm23蛋白阳性表达率无淋巴结转移者显著高于有淋巴结转移者(P<0.01),与LSCC淋巴结转移呈负相关。而且,在淋巴结转移者中HER-2/neu蛋白的阳性表达率与nm23蛋白呈负相关。结论:HER-2/neu及nm23蛋白异常表达在LSCC发生、发展和淋巴结转移中可能起重要作用。Objective：To explore the relationship between the expressions of HER-2/neu,nm23 protein and local invasion and lymp node metastasis of LSCC. Method： The expression of HER-2/neu,nm23 protein was detected by immunohistochemical technique in 56 patients with human LSCC. Result：The positive expression rate of HER-2/neu protein in LSCC was not correlated with histological grade（ P〉0.05）. There was a significant relationship between the expression of HER-2/neu and the clinical stages, lymph node metastasis （ P〈0. 05, P〈0. 01）. The positive expression rate of nm23 protein was significantly higher in the group without lymph node metastasis than those with lymph node metastasis （ P〈0. 01）. The negative correlation was found between the nm23 expression and lymph node metastasis of LSCC. Furthermore, the negative correlation was found between the positive expression of HER-2/neu protein and the positive expression of nm23 protein in the group with lymph node metastasis. Conclusion：The abnormal expression of HER-2/neu, nm23 protein play an important role in development and lymph node metastasis of LSCC.

关 键 词：喉肿瘤 癌 鳞状细胞 HER-2/NEU蛋白 NM23蛋白 肿瘤转移 

分 类 号：R739.65[医药卫生—肿瘤]