SA-DTPA-Gd经腹腔和静脉给药后荷人结肠癌裸鼠的MR增强对比研究  

Comparative studies on MR enhancement of SA-DTPA-Gd after different routes of administration in nude mice bearing human colon carcinoma

作　　者：叶靖[1] 许乙凯[1] 刘岘 陆雪松[1] 许鹏君[1] 黄其鎏[1] 蒋志强[1] 吕国士[1] 

机构地区：[1]南方医科大学南方医院,广东广州510515 [2]广州省中医院放射科,广东广州510102

出　　处：《中国临床医学影像杂志》2006年第3期167-170,共4页Journal of China Clinic Medical Imaging

基　　金：国家自然科学基金(30371608);广东省自然科学基金(020053)

摘　　要：目的:探讨不同的给药途径对MR预定位免疫成像靶瘤性致增强作用的影响。方法:2组荷人结肠癌细胞裸鼠分别经腹腔和静脉注射SA-DTPA-Gd,检测各组肿瘤组织和肝组织的信号强度。结果:肿瘤在静脉给药后6h强化率达到最高(70.2%),而腹腔组中9h肿瘤的强化率最高(46.4%),两者之间具有显著差异;肝组织在腹腔组中峰值强化率为23.7%,而静脉组中最高为20.4%,两者之间差异不显著。结论:静脉给药更有利于肿瘤的SA-DTPA-Gd摄取并具有更为均匀的瘤内分布。Objective： To investigate MR enhancement of different administration routes in MR pretargeting immunology imaging. Methods： Two groups of mice were injected with SA-DTPA-Gd through tail vein（iv） and intra-peritoneal cavity（ip） respectively, and the MR signal intensity of tumor and liver was determined. Result： In iv group and ip group the maximum enhancement rate of tumor was 70.2% and 46.4% respectively, and there was significant difference. The maximum enhancement rate of liver was 23.7% in ip group and 20.4% in iv group, and there was no signifinant difference. Condusion： Intravenous injection is in favor of SA-DTPA-Gd＇s accumlation in tumor than intraperitoneal injection, and a more homogenious intratumoral distribution is archived.

关 键 词：结肠肿瘤 动物替代试验 磁共振成像 

分 类 号：R735.35[医药卫生—肿瘤] R445.2[医药卫生—临床医学]