促愈颗粒对大鼠胃黏膜保护作用的实验研究  

Experimental Study of Cuyu Granule on Rats' Gastric Mucosa for Protective Effect

作　　者：杨海芳[1] 时昭红[2] 张介眉[2] 周慧芳[1] 

机构地区：[1]湖北中医学院,2003级研究生湖北武汉430061 [2]武汉市中西医结合医院,湖北武汉430022

出　　处：《山西中医学院学报》2006年第1期28-30,共3页Journal of Shanxi College of Traditional Chinese Medicine

摘　　要：目的:研究促愈颗粒对胃溃疡愈合质量的影响。方法:用冰醋酸制备大鼠慢性胃溃疡模型,随机分为模型对照组、促愈颗粒组、雷尼替丁组3组,分别以生理盐水、促愈颗粒和雷尼替丁灌胃。用HE染色定量观察胃溃疡大鼠黏膜肌缺损宽度和再生黏膜厚度,用Masson染色观察并计算胶原纤维密度,用硝酸还原法检测血清NO的含量。结果:促愈颗粒组和雷尼替丁组再生黏膜厚度高于生理盐水组(P<0.01),黏膜肌层缺损宽度小于生理盐水组(P<0.01),血清NO含量高于生理盐水组(P<0.05);促愈颗粒组再生黏膜厚度高于雷尼替丁组(P<0.05),黏膜肌层缺损宽度小于雷尼替丁组(P<0.05),血清NO含量高于雷尼替丁组(P<0.01)。结论:促愈颗粒能提高溃疡愈合质量,这可能是促愈颗粒临床抗消化性溃疡复发的机理之一。Objective：To Study the effect of Cuyu granule on rats for quality of ulcer healing （ QOUH ）. Methods： The model rats of chronic gastric ulcer were prepared with acetic acid and randomly divided into A,B and C group, which were given normal saline, Cuyu granule and Ranitidine respectively. HE mucus stain was used to observe the width of defective muscularic mucosa and the thickness of regenerative gastric ulcer, Masson mucus stain was used to obeserve the density of collagen fibre, the method of nitric acid reductase was used to determined the level of serum NO. Results：The thickness of regenerative mucosa of B and C group were significantly thicker than that of A group （P〈0.01）, the width of defective muscularis mucosa were significantly narrower than that of A group （P〈0.01）, the level of serum NO were higher than that of A group （ P〈0.05 ）. Furthermore, the thickness of regenerative mucosa of B group were significantly thicker than that of C group （ P〈0.05 ）, the width of defective muscularis mucosa of B group were significantly narrower than that of C group （ P〈0.05 ）, and the level of serum NO of B group were higher than that of C group （ P〈0.01 ）. Conclusion：Cuyu granule can improve QOUH. tt is one of possible mechanisms for preventing the relaps of peptic ulcer by using Cuyu granule in clinic.

关 键 词：促愈颗粒 胃溃疡 胃黏膜 再生黏膜 溃疡愈合质量 

分 类 号：R573.1[医药卫生—消化系统]