VEGF-C和MMP-7的表达与胃癌侵袭转移的关系  

The expression of VEGF-C and MMP-7 in gastric carcinoma and their correlation with tumor invasion and metastasis

作　　者：洪士开[1] 李绍森[1] 陆云飞[1] 林进令[1] 廖清华[1] 林坚[1] 黄源[1] 曾健[1] 

机构地区：[1]广西医科大学第一附属医院胃肠外科,广西南宁530021

出　　处：《中国普通外科杂志》2006年第2期90-93,共4页China Journal of General Surgery

摘　　要：目的探讨胃癌中血管内皮生长因子C(VEGF-C)和基质金属蛋白酶7(MMP-7)的表达及两者与胃癌侵袭和淋巴结转移的关系。方法采用SP免疫组化技术,分别检测6 0例胃癌组织、癌旁组织及3 0例癌周区域淋巴结中VEGF-C及MMP-7的表达水平。结果VEGF-C和MMP-7在胃癌组织中的阳性表达率明显高于正常胃黏膜及癌旁组织;在区域淋巴结癌转移组中的阳性表达率明显高于无癌转移组(P<0.0 1);伴有淋巴结转移的胃癌组织中VEGF-C,MMP-7的阳性表达率明显高于无淋巴结转移组(P<0.0 5);VEGF-C,MMP-7表达与淋巴结转移、淋巴管侵犯、浸润深度、TNM分期有密切关系(P<0.0 5)。结论VEGF-C和MMP-7在胃癌中的高表达与胃癌浸润侵袭程度、淋巴结转移有密切关系。Objective To investigate the expression of vascular endothelial growth factor-C （VEGF-C） and matrix metalloproteinase-7 （MMP-7） in gastric carcinoma and their correlation with tumor invasion and metastasis. Methods Streptavidin peroxidase immunohistochemistry technique （SP）was used to detect the expression of VEGF-C and MMP-7 in 60 gastric carcinoma specimens, 60 specimens of gastric mucosa adjacent to carcinoma, and 30 regional lymph node specimens. Results The positive expression rate of VEGF-C, MMP-7 in gastric carcinoma was markedly higher than that in normal gastric mueosa and gastric mueosa adjacent to carcinoma . The positive expression rates of VEGF-C and MMP-7 in metastatic regional lymph nodes were significantly higher than that in non-metastatic regional lymph nodes （ P 〈 0. 01 ）. The positive expression of VEGF-C and MMP-7 in gastric carcinoma speemens in patients with lymphatic metastasis was significantly higher than that in without lymphatic metastasis （ P 〈 0.05 ） . The positive expression level of VEGF-C and MMP-7 was significantly correlated with lymph node metastasis, lymphatic vessel invasion, tumor infiltration depth and UICC TNM staging （ P 〈 0. 05 ）. Conclusions The increased expression of VEGF-C and MMP-7 in gastric carcinoma closely correlates with tumor invasion and metastasis.

关 键 词：胃肿瘤/病理学 肿瘤浸润力 血管内皮生长因子C 基质金属蛋白酶-7 

分 类 号：R735.2[医药卫生—肿瘤] R73-37[医药卫生—临床医学]