VDR与乳腺癌临床病理因素的关系  

Relationship between vitamin D receptor and clinical pathology of mammary carcinoma

作　　者：关爱华[1] 姜伟栋[1] 关文曾[1] 

机构地区：[1]吉林大学第二医院基本外科,130041

出　　处：《中国妇幼保健》2006年第5期692-694,共3页Maternal and Child Health Care of China

摘　　要：目的:研究维生素D受体(VDR)在乳腺癌组织中的表达,初步探讨维生素D受体与乳腺癌各病理类型、雌孕激素受体表达情况、肿瘤大小、患者年龄及临床分期的相关性。分析VD/VDR对乳腺癌治疗的意义。方法:采用免疫组化S-P法对65例乳腺癌组织及30例乳腺良性肿瘤组织进行维生素D受体标记。结果:4种病理类型的乳腺癌组织中VDR的表达有显著性差异(P<0.05),VDR的表达与雌、孕激素受体表达情况、肿瘤大小、患者年龄及临床分期无相关性。结论:在临床上检测VDR并应用VD的类似物进行乳腺癌治疗。Objective： To explore the expression of vitamin D receptor （VDR） in mammary carcinoma tissue and analyze the correlation among pathological types, estrogen receptor, progestogen receptor expressions, tumor size, patients age and clinical staging, and the significance of VD/VDR in treatment of mammary carcinoma. Methods： VDRs were labeled in mammary carcinomal tissue of 65 casese and benign mammary tumor of 30 cases by S - P method. Results： There were significant difference in VDR expressions of 4 kinds of pathological types of mammary carcinoma. （ P 〈0. 05）, expressions of VDR had no relation to expressions of estrogen receptor, progestogen receptor expressions, carcinoma size, patients＇age and clinical staging. Conclusion： VDR determination and VD analog could be applied to treatment of mammary carcinoma.

关 键 词：乳腺癌 维生素D受体(VDR) 免疫组化 

分 类 号：R737.9[医药卫生—肿瘤]