一氧化氮与多发性硬化  

Nitric Oxide and Multiple Sclerosis

作　　者：尚宏[1] 付锦（审校者）[2] 

机构地区：[1]哈尔滨医科大学第二临床医学院神经内科（硕士研究生）,150086 [2]哈尔滨医科大学第二临床医学院神经内科

出　　处：《国际免疫学杂志》2006年第2期116-119,共4页International Journal of Immunology

基　　金：黑龙江省省攻关基金资助项目(2005G1491-00)

摘　　要：多发性硬化是中枢神经系统一种广泛脱髓鞘性自身免疫性疾病,其发病机制与免疫调节功能异常密切相关。一氧化氮具有重要的免疫调节作用,它与多发性硬化的发生、发展有着密切的关系。一氧化氮在多发性硬化的经典动物模型—实验性变态反应性脑脊髓炎的预防和治疗中发挥重要作用。因此,对一氧化氮的深入研究将为临床防治多发性硬化等自身免疫疾病提供有价值的新思路。Multiple sclerosis is an immune - mediated demylinating disease of the central nervous system, its pathogenety is closely related to the abnormality of immuoregulation . Nitric oxide has important effect on immunological regulation, it closely connects with the genesis and development of multiple sclerosis . Nitric oxide plays an important role in the prevention and treatment of experimental allergic encephalomyelitis , which is the classical experimental model of multiple sclerosis . Therefore the deep research of nitric oxide will provide a new valuable way of the preven- tion and cure of autoimmtme disease, such as multiple sclerosis.

关 键 词：一氧化氮 多发性硬化 实验性变态反应性脑脊髓炎 

分 类 号：R744.51[医药卫生—神经病学与精神病学]