骨形成蛋白缓释生物膜的临床应用  

Clinical Application of Bone Morphogenetic Protein Sustained Release Biofilms

作　　者：杨卫红[1] 谢素英 

机构地区：[1]江门市疾病预防控制中心口腔科,广东江门529000 [2]江门市人民医院口腔科,广东江门529000

出　　处：《西南军医》2006年第2期14-15,共2页Journal of Military Surgeon in Southwest China

摘　　要：目的观察骨形成蛋白缓释生物膜在活髓保存治疗中的效果。方法以聚乙烯醇(polyvinyl alcohol,PVA)为缓释载体,骨形成蛋白(bone morphogenetic protein,BMP)为主药,并添加适量的甲硝唑制成膜(实验组)。与成品氢氧化钙糊剂(对照组),分别用于盖髓术,观察其疗效。结果应用BMP缓释生物膜经过1、3、6个月的组织学及X线片检查,可见1个月时牙本质桥形成,6个月时,临床治愈率达97.05%,而氢氧化钙糊剂的治愈率是92.86%,但无统计意义。结论BMP缓释生物膜盖髓的临床效果不低于氢氧化钙。而且操作简便、快捷,可为新一代生物盖髓剂的开发运用打下基础。Objective To observe the effect of bone morphogenetic protein （BMP） sustained release biofilms in the live-marrow conservation cure. Methods A film was gained in the test group by adding polyvinyl alcohol （PVA） as the carrler,bone morphngenetic protein （BMP） as the main drug and plus proper Metronidazule, a calcium hydroxid paste was applied to the control group,both were used in pulp capping,and then the effect was observed. Results Histological checking and X-ray film checking were made 1 month, 3 months and 6 months after the application of bone morphogenetic protein sustained release biofilms, dentin bridge was fromed in 1 month, the curative rate reached 97.05 % in the 6th month. The curative rate of calcium hydroxid paste was 92.86%, having no statistical significance. Conclusions The curative effect of BMP sustained release biofilms is better than that of calcium hydroxid paste ; the BMP sustained release biofilms would be the leader of new-stale medicament of pulp capping as it is simple in handling and with prompt curative effect.

关 键 词：骨形成蛋白(BMP) 聚乙烯醇(PVA) 缓释生物膜 盖髓剂 牙本质桥 

分 类 号：R781.1[医药卫生—口腔医学]