多巴胺D_2受体基因多态性与精神分裂症的关系  

ASSOCIATION OF DOPAMINE D2 RECEPTOR GENE POLYMORPHISM WITH SCHIZOPHRENIA

作　　者：周儒伦[1] 周朝凤[1] 王玉凤[1] 沈渔 范建华[1] 

机构地区：[1]北京医科大学精神卫生研究所

出　　处：《北京医科大学学报》1996年第1期23-25,共3页Journal of Peking University(Health Sciences)

基　　金：WHO西太区资助课题

摘　　要：目的：探讨多巴胺Ｄ＿２受体基因多态与精神分裂症的关系。方法：运用人为介入内切酶位点的ＰＣＲ技术，对１０５名精神分裂症患者及１０８名对照成员进行多巴胺Ｄ＿２受体（ＤＲＤ２）基因第３ｌｌ密码子Ｓｅｒ３１１→Ｃｙｓ３ｌｌ错义突变检测。结果：Ｓｅｒ３ｌｌ／Ｃｙｓ３ｌｌ基因型在患病组和对照组中出现比例经统计学检验无显著差异，Ｓｅｒ３１１／Ｃｙｓ３１１占低发病年龄组和有家族史组的比例略高于对照组。结论：ＤＲＤ２基因结构多态性可能与精神分裂症某些亚型相关。bjective:To explore the relationship between polymorphism of DRD2 and schizophrenia.Methods:105 schizophrenics and 108 controls have been tested on the dopamine D_2 receptor gene using artificial PCR-RFLP method.Results:The distribution of Ser 311/Cys 311 allele had no statistically significant difference between samples and controls.The schizophrenics with Cvs311 tended to have a lower age of onset and a positive family history.Conclusions:The Ser311→Cys311 variant may affectthe onset of some subtypes of schizophrenia.

关 键 词：受体 多巴胺D2 精神分裂症 

分 类 号：R749.302[医药卫生—神经病学与精神病学]