Enantioseparation of Zolmitriptan by HPLC  

高效液相色谱法分离佐米曲普坦对映体(英文)

作　　者：尹燕杰[1] 张启明[2] 李慧义[2] 张秋生[1] 田颂九[2] 

机构地区：[1]黑龙江省药品检验所,黑龙江哈尔滨150001 [2]中国药品生物制品检定所,北京100050

出　　处：《Journal of Chinese Pharmaceutical Sciences》2006年第1期55-58,共4页中国药学（英文版）

摘　　要：Aim To establish a HPLC method for the separation of the enantiomers of zolmitriptan. Methods The separations were performed on Chiralcel OJ column with hexane-ethanol-diethylamine（85：15：0.2） as mobile phase at a flow rate of 0.8 mL·min^-1 and detecttion wavelength of 227 nm at 35 ℃. Several related parameters for separation were studied. Results Baseline separation （Rs 〉 1.5） was easily obtained in the case, and the R-isomer impurity in zolmitriptan was determined. Conclusion The method developed in this study has been successfully applied for quality-control purposes.目的建立一种高效液相色谱法分离佐米曲普坦对映体。方法采用Chiralcel OJ色谱柱,以正己烷-乙醇-二乙胺(85∶15∶0.2)为流动相,检测波长227nm,流速0.8mL·min-1,柱温35℃,并对一些影响分离的参数进行了研究。结果佐米曲普坦对映体得到基线分离,并对佐米曲普坦样品中的R异构体杂质进行了检查。结论该方法已成功地应用于佐米曲普坦的质量控制。

关 键 词：ENANTIOSEPARATION ZOLMITRIPTAN HPLC chiral stationary phases 

分 类 号：R917[医药卫生—药物分析学]