温肾方对实验性自身免疫性甲状腺炎大鼠白细胞介素-1α表达的影响  

Effect of wenshenfang on the relative expression of IL-1α in experimental autoimmune thyroiditis

作　　者：曹晓蕾[1] 顾志峰[2] 余江毅[3] 秦文浩[2] 崔世维[2] 

机构地区：[1]南通大学基础医学院病理解剖学教研室,江苏226001 [2]南通大学附属医院内分泌科 [3]江苏省中医院内分泌科

出　　处：《中国交通医学杂志》2006年第1期45-46,48,共3页Chinese Medical JOurnal of Communications

基　　金：江苏省科技厅课题号BK2002135;省人事厅资助课题。

摘　　要：目的:研究温肾方对大鼠实验性自身免疫性甲状腺炎(EAT)白细胞介素-1(IL-1)的影响。方法:通过RT-PCR方法对SD大鼠EAT甲状腺组织IL-1进行测定,了解温肾方等对EAT的干预机制。结果:EAT大鼠的IL-1水平明显高于温肾方组、雷公藤组、对照组(P<0.05)。结论:温肾方可能通过对IL-1的抑制而对EAT起到预防及治疗作用。Objective：To Investigate the effect of Wenshenfang in the treatment of experimental autoimmune thyroiditis （EAT） by observing IL-1 in thyroid tissues. Methods： EAT model was established in SD rats by injection of swine thyroglobin combined with adjuvant. Its mechanism was studied by detection of the relative expressions of IL-1. Result： The relative expressions of IL-1 were fewer in normal controls and the rats treated with Tripterygium Wilfordii Hook for Wenshenfang than in EAT rats without treatment （P〈0.05）. Conclusion： Wenshenfang has a therapeutic effect on EAT. The mechanism by which Wenshenfang exerts its effects may be by the suppression of relative expressions of IL-1 in thyroid cells.

关 键 词：实验性自身免疫性甲状腺炎 细胞因子 白细胞介素-1 

分 类 号：R289.1[医药卫生—方剂学]