the National Natural Science Foundation of China(No.82071838,81801610,81771767,and 82001737);Postgraduate Research&Practice Innovation Program of Jiangsu Province,China(No.KYCX20_2842,KYCX20_2846,and KYCX20_2848);Science and Technology Project of Jiangsu Province,China(No.BE2018671);Clinical Research Center of Stem Cells,Affiliated Hospital of Nantong University(No.HS2018001)。