70岁以上老年人口腔黏膜鳞癌综合治疗的疗效分析  

Study of curative effect of combined therapy in the elderly patients with oral squamous-cell carcinoma

作　　者：叶茂昌[1] 王来平[1] 李容新[1] 朱祖武[1] 陈梅梅[1] 康然刚[1] 周媛[1] 

机构地区：[1]安徽省立医院口腔医学中心颌面外科,合肥市230001

出　　处：《中华老年医学杂志》2006年第3期192-194,共3页Chinese Journal of Geriatrics

摘　　要：目的探讨70岁以上老年人口腔黏膜鳞癌综合治疗的疗效及其围手术期的处理原则。方法收集1991-2001年行计划性诱导性顺铂为主综合治疗的年龄≥70岁(≥70岁组)的72例患者治疗情况,与同期同治疗方案年龄<70岁(<70岁组)72例患者和同期单纯手术根治的26例患者(单纯手术组)的情况进行对比。结果≥70岁组12、24、36个月生存率分别是84.6%、73.0%和68.5%,<70岁组为85.8%、75.3%和69.1%,手术组为52.7%、48.5%和39.7%。≥70岁组和<70岁组3年生存率比较,差异无统计学意义(P>0.05);≥70岁组和手术组3年生存率比较,差异有统计学意义(P<0.05)。结论对70岁以上老年人口腔黏膜鳞状细胞癌采用以顺铂为主的综合治疗,可提高患者3年生存率,60～80mg 的顺铂剂量70岁以上老年人能够耐受。Objective To investigate the curative effect of combined therapy and doctrine in perioperative period of the elderly above seventy years of age with oral squamous-cell carcinoma. Methods All cases with squamous-cell carcinoma were divided into 3 groups. Group A （72 cases） were treated with combined therapy mainly by cisplatin, Group B （72 cases） were much younger of the same disease and accepted the same treatment as group A. While group C （26 cases） accepted simply radical excision. Results The survival rates of A group at 12,24,36 months were 84. 6%, 73.0% and 68. 5% ;B group were 85.8% ,75.3% and 69. 1% ;while C group dropped to 52.7%,48. 5%和 39. 7%. No statistic significance was found between A and B（P〉0. 05）. There was significant difference in the 3-year survival rate between A and C group. Conclusions The 3-year survival rate was dramatically increased with combined therapy mainly by cisplatin, the dose of 60 - 80 mg is tolerant for the elderly aged above seventy years, and perioperation complications can be cured.

关 键 词：口腔黏膜 癌 鳞状细胞 治疗结果 

分 类 号：R739.8[医药卫生—肿瘤]