衰老与年龄相关性黄斑变性  

Aging and age-related macular degeneration

作　　者：何世坤[1] 姜岩 

机构地区：[1]美国南加州大学Keck医学院,Doheny眼科研究所,90033 [2]辽宁省本溪市中心医院眼病防治中心

出　　处：《中华眼科杂志》2006年第3期278-282,共5页Chinese Journal of Ophthalmology

摘　　要：衰老是导致眼部生物学改变的常见原因,特别对视网膜组织的影响更明显。已往的研究发现,年龄相关性黄斑变性(AMD)的病理改变主要表现为视网膜色素上皮的Bruch膜和脉络膜毛细血管复合体的变化,该复合体随着年龄的增加其功能和结构亦发生异常改变。衰老因素在AMD早期阶段的病理改变中起重要作用,但衰老因素并不是导致AMD的直接原因,有多种因素涉及AMD的病理始动过程。为此,该文作者就新近有关衰老因素对AMD发生过程的影响进行了简要综述,旨在探讨衰老与AMD的关系。(中华眼科杂志,2006,42:278-282)Aging is a common feature of biological changes in the eye, especially in the retina. It is recognized that the pathogenesis of age-related macular degeneration （AMD） involves changes of RPE-Bruch membrane and choroid capillaries complex, which includes function and structure abnormal in the complex accompanied with aging processes. Aging may be an important event to contribute to the pathogenesis of AMD, but aging dose not directly led to the occurrence of AMD, multifactor is involved in the initiation of the pathogenesis of AMD. Therefore, this review is summarizing the latest concepts of the rale of aging in the occurrence of AMD.

关 键 词：衰老 色素上皮 眼 黄斑变性 

分 类 号：R774.5[医药卫生—眼科] R339.38[医药卫生—临床医学]