选择性肠道清洁预防肝硬化自发性细菌性腹膜炎的疗效  

The prophylactic effect of selective intestinal decontamination for spontaneous bacterial peritonitis in cirrhosis

作　　者：龚飞跃[1] 陈渝萍[1] 陈剑鸣[1] 黄唯[1] 黄永强[1] 孙达春[1] 

机构地区：[1]广东省珠海市人民医院、暨南大学医学院第三附属医院,519000

出　　处：《中华腹部疾病杂志》2006年第3期157-159,共3页Chinese Journal of Celiopathy

摘　　要：目的观察采用选择性肠道清洁（SID）对肝硬化腹水有自发性细菌性腹膜炎（SBP）易患因素的病人预防SBP发生的疗效。方法①短期SID：肝硬化腹水有易患SBP因素住院病人60例分为预防组30例（除常规治疗外，给予口服诺氟沙星400mg，2次／d，共7d）和对照组30例（仅给予常规治疗）两组；②长期SID：肝硬化腹水无SBP的易患SBP病人50例，分为预防组25例（除常规治疗外加用口服诺氟沙星400mg，2次／d，3d／周，共半年）和对照组25例（仅给予常规治疗）两组。结果①短期SID中，预防组SBP发生率（6.67％）明显低干对照组（16.67％）（P〈0.05）；②长期SID中，预防组发生SBP（8％）明显低干对照组（32％）（P〈0.05），预防组腹水总蛋白和补体C3较治疗前显著增加（P〈0.05），而对照组治疗前后无明显变化（P〉0.05）。两方案中，预防组死亡例数少于对照组，未见明显副反应发生。结论短期或长期SID对存在SBP易患因素肝硬化腹水病人SBP的发生具有良好的预防作用。AIM To investigate the prophylactic effect of selective intestinal decontamination（SID）with norfloxacin against spontaneous bacterial peritonitis（SBP）in patients with cirrhosis ascites, METHODS Consecutive patients with high risk of SBP took part in a short - term trial（n = 60）or a long- term one（n = 50）. Prophylactic treatment with norfloxacin at 400mg twice a day was taken for 7 days（n = 30） in the short- term trial, or three days every week for 6 months（n = 25）in the long- term trial, RESULTS For patients treated with or without norfloxacin, SBP developed in 6, 67 % or 16.67 % patients（ P 〈 0.05）in the short- term trial, 8 % or 32 % （ P 〈0.05） in the long - term trial. Total protein and C3 concentration were increased in ascitic fluid in norfloxacin- treated patients（ P 〈 0. 05）, CONCLUSION Selective intestinal decontamination with norfloxacin was effective either in a short - term or a long- term prevention of SBP in patients with cirrhosis,

关 键 词：选择性肠道清洁 预防 自发性细菌性腹膜炎 肝硬化 

分 类 号：R572.2[医药卫生—消化系统]