鼻咽癌CT/MRI配准方法的临床研究  

Clinical registration between CT and MRI of nasopharyngeal carcinoma

作　　者：付杰[1] 胡超苏[1] 胡伟刚[1] 陆惠忠[1] 何少琴[1] 

机构地区：[1]复旦大学附属肿瘤医院放疗科,上海200032

出　　处：《中华放射肿瘤学杂志》2006年第2期85-88,共4页Chinese Journal of Radiation Oncology

摘　　要：目的 探讨鼻咽癌CT／MRI的临床配准方法并评价配准效果。方法 8例未经治疗的鼻咽癌患者采用相同放疗体位和面罩固定方法，Cr、MRI扫描后全部图像经网络传输至AcQSIM4．9．2及Pinnacle3 V7．0工作站，分别由两名医师和一名物理师在AcQSIM4．9．2采用点标记法、交互法及在Pinnacle3 V7．0上采用归一化互信息法来配准。采用盲法由两名医师分别在不同工作站上目测评价，评价配准结果采用四点法：极差、差、良、很好；评价配准时间采用三点法：短时（（1min）、长时（1～3min）、很长（〉3min）。结果 归一化互信息法较交互法、点标记法更为准确，配准速度最快。医生组较物理师配准更为准确，速度快，其中点标记法医生组较物理师配准更为准确，速度快，而归一化互信息法和交互法医生组与物理师配准准确性及速度相当。结论 归一化互信息法在速度和Robust上占优势，因由软件自动配准、人为因素影响较小故适合放疗计划配准应用。Objective To explore and evaluate the different registration methods between CT and MPA of nasopharyngeal carcinoma. Methods cr and MPd scans of 8 untreated nasopharyngeal carcinoma patients were carried out in treatment position using mask immobilization. All images were transformed and registered at Ac- QSIM4.9.2 and Pinnacle3 V 7.0 workstation by two physicians and one physicist respectively, as to the pointmarker, interactive, normalized mutual information registration. Two physicians evaluated the results and time of registration with four points based on visual evaluation and three points based on registration time were recorded and assessed as well. The four points were： worst; worse; better; best. The three points were： short time（ 〈 1 min） ; long time（1 ～3 min） ; and longer time（ 〉 3 min）. Results Normalized mutual information registration was the method that the results and times oir registration were better than the others. The results of registration were improved by the physicians rather than the physicist, especially the point-marker method. The results of registration were similar between physicians and physicist with interactive, normalized mutual information registration. Conclusion Compared with other methods, normalized mutual information method is adapted to registration during treatment planning. Because it is automatically carried on by software and coefficient, and showing supoeriority in robust with less subiective effect, it is suggested for the registration of radiotherapeutic planning.

关 键 词：鼻咽肿瘤 图像处理 计算机辅助 评价研究 

分 类 号：R739.63[医药卫生—肿瘤]