社区慢性精神分裂症患者服药依从性研究(Ⅲ)──酚噻嗪类药物尿液检测法结果分析  

Compliance of chronic schizophrenic patients in the community (study Ⅲ): The determination of phenothiazines by urine test

作　　者：朱紫青[1] 张明园[1] 王克勋[1] 李松[2] 

机构地区：[1]上海市精神卫生中心,200030 [2]云南省红河州第二人民医院

出　　处：《临床精神医学杂志》1996年第4期198-200,共3页Journal of Clinical Psychiatry

基　　金：上海市精神病社区防治康复协作组的课题

摘　　要：以尿液检测的方法，对上海城乡社区样本进行依从性研究。对象为服用酚噻嗪类药物的130例慢性精神分裂症康复患者，尿测总次数为375次，近92％的患者尿液呈现阳性（＋～＋＋＋）反应。与面询法及药片计数法比较的结果示：PPV分别达到96．0％和97.4％；阳性结果LR分别为2.31和3．33；NPV分别为67％和74％；一致性检测Kappa值分别为0．21和0．42（P均＜0．01）。作者对三种依从性研究方法的可行性及意义进行了分析。Objective: To study the use of urine test in examining the compliance of chronic schizophrenic pa-tients in the community. Method: 130 chronic schizophrenic patients who received phenothiazines under-went 375 times of urine test. The results were compared to data from the patients' self report and tabletcounts. Results: 92% of subjects were found to have a positive (+～+++) urine test result. When com-pared to the patients' self report and tablet counts, the positve predictive value was 96. 0% and 97. 4 %,the positive likelihood ratio was 2. 31 and 3.33, while the negalive predictive value was 67. 0%and74. 0% respectively (Kappa= 0. 21, 0. 42. P<0. 01 ). Discussion: The advantages and disadvantages ofthe three methods of assessing compliance were discussed.

关 键 词：精神分裂症 药物疗法 尿液检测 酚噻嗪类药 

分 类 号：R749.305[医药卫生—神经病学与精神病学]