降纤酶对缺血性脑卒中急性期血浆VEGF等4项生物分子的影响  

Effects of defibrinogenase on four plasm biomoleculs levels in acute cerebral infarction

作　　者：孙淑玉[1] 许继平[2] 刘震[2] 范金萍[2] 齐宏顺[2] 

机构地区：[1]山东大学东校区校医院,山东济南250100 [2]山东大学第二医院神经内科,山东济南250033

出　　处：《山东大学学报（医学版）》2006年第3期307-309,共3页Journal of Shandong University:Health Sciences

摘　　要：目的:观察降纤酶治疗早期缺血性脑卒中前后血浆中血管内皮生长因子(vascular endothelialgrowth factor VEGF)、内皮素(endothelin ET-1)、P-选择素(P-selectin)和血小板活化因子(platelet activating fac-tor PAF)水平的变化,并探讨其机理。方法:随机将114例急性缺血性脑卒中患者分为降纤酶组和对照组,观察其临床疗效,检测凝血功能和VEGF、ET-1、P-selectin、PAF等4项生物分子水平的变化。结果:治疗后2组临床疗效经Ridit分析差异无统计学意义(P>0.05),2种药物对凝血功能和4项血浆生物分子水平的影响差异有统计学意义(P<0.01),降纤酶抗凝明显,且能降低Fbg水平,对ET-1、P-selectin和PAF有抑制作用,能提高VEGF的血浆含量。低分子肝素钠抗凝明显,也能降低Fbg水平,对PAF有抑制作用。结论:降纤酶可提高血浆VEGF水平,抑制血浆ET-1、P-selectin和PAF的合成。Objective： To explore the changes of plasma vascttlar endothelial growth factor（VEGF）, endothelin（ET-1）, P-selectin and platelet activating factor（ PAF） in patient with ischemic stroke treated with defibrinogenase. Method： The blood coagulation function and the concentration of VEGF, ET-1, P-seleetin and PAF were determined in acute cerebral infarction in 66 patients with defibrinogenase and 48 with low dose heparin before and after treatment. Result： Excluding curative effect, there was significant difference between the two groups on the blood biochemicals items and plasm biomoleculs levels. The Flag decreased, the level of ET-1, P-seleetin and PAF were depressed, and the plasm VEGF level rised in the defibrinogenase group, whereas only Flag and the plasm PAF were depressed by low dose heparin. Conclusion： Defibrinogenase seems to have a salutary effect on descending of the Flag, rising of the plasm VEGF levels and depressing of the synthesis of the ET-1, P-selectin, and PAF.

关 键 词：脑梗塞 降纤酶 血管内皮生长因子 

分 类 号：R743.3[医药卫生—神经病学与精神病学]