18例胃肠道间质瘤临床病理研究及免疫组化分析  

A clinicopathologic and immunohistochemical study on 18 cases of gastrointestinal stromal tumors

作　　者：温建成[1] 黄小萍[1] 苏少雪[1] 王延红[1] 刘俊斌[1] 蔡岳华[1] 

机构地区：[1]潮州市中心医院,广东潮州521000

出　　处：《基层医学论坛》2006年第4期291-293,共3页The Medical Forum

摘　　要：目的探讨胃肠道间质瘤组织病理学形态特征和免疫组化特点。方法对18例胃肠道间质瘤进行常规病理检查和免疫组化CD117、CD34、Vimentin、Desmin、SMA、S-100和NSE染色。结果胃肠道间质瘤由梭形细胞和上皮样细胞组成,其中良性3例,潜在恶性9例,恶性6例,绝大多数病例肿瘤细胞CD117和CD34标记阳性。结论胃肠道间质瘤是胃肠道常见的间叶源性肿瘤,缺乏定向分化。肿瘤细胞CD117和CD34标记阳性对胃肠道间质瘤的诊断具有非常重要的价值。Objetive To study the clinicopathological and immunohistochemical features of gastrointestinal stromal tumors （GISTs）. Methods 18 cases of GISTs were studied by routine pathologic examination and immunohistochemical stains of CD117, CD34, Vimentin, Desmin, SMA, S-100 and NSE. Results 18 cases of GISTs consisted of two basic cell types： spindle and epithelioid cells, among them, 3 cases of benign GIST, 9 cases of GIST with bordenline malignancy and 6 cases of malignant GIST. Most cases of GISTs were spindle cell type （77.8%）. The positive expression rate of CD117 was 100%, that of CD34 was 83.3%. Conclusion GISTs that have no evidence of specific differentiation are common mesenchymal tumors of gastrointestinal tract. The positive expression of CD117 and CD34 plays a very important role in the diagnosis of GISTs.

关 键 词：胃肠道间质瘤 免疫组织化学 CD117 CD34 

分 类 号：R735[医药卫生—肿瘤] R322.2[医药卫生—临床医学]