甲状腺功能低下与亢进大鼠模型的几项生化指标的检测  

The Examination of Several Biochemical Indexes in the Hypothyroid and HypertHyroid rats

作　　者：庄晓燕[1] 于冬梅[1] 赵艳[1] 

机构地区：[1]锦州医学院,锦州121001

出　　处：《数理医药学杂志》2006年第2期136-138,共3页Journal of Mathematical Medicine

摘　　要：目的:探讨甲状腺功能低下(甲低)及甲状腺功能亢进(甲亢)模型大鼠的甲状腺功能改变对血钙和血磷的影响。方法:制备甲低及甲亢大鼠模型,测定其血清T3、T4、TSH、钙、磷的含量变化。结果:甲低大鼠血清T3、T4和TSH浓度分别为0.27±0.08nm o l/L、25.87±2.83nm o l/L和3.36±0.42mU/L,与对照组血清T3(0.97±0.11nm o l/L)和T4(68.74±7.57nm o l/L)相比较,均明显降低(P<0.0001),有极显著差异;而血清TSH较对照组TSH含量(1.72±0.43mU/L)显著升高(P<0.0001)。甲亢大鼠T3(9.24±1.56 nm o l/L)和T4(155.73±13.98nm o l/L)含量比对照组均显著升高(P<0.0001),而TSH含量仅为0.37±0.06mU/L,与对照组相比明显降低(P<0.0001)。对照组血钙(C a2+)和血磷(HPO42-)含量分别为2.37±0.30mm o l/L和2.56±0.10mm o l/L;甲低组血钙为2.27±0.15mm o l/L,血磷为2.33±0.10mm o l/L;甲亢组血钙含量为6.17±1.42mm o l/L,血磷含量为3.84±1.13mm o l/L。结论:甲亢大鼠血钙和血磷含量较正常大鼠明显升高。甲低大鼠血清钙、磷含量与对照组大鼠比较均有所下降,但无统计学意义。Objective： To investigate the effect oi the thyroid functional hormonal changes in the hypothyroid and hyperthyroid rats on serum calcium and serum phosphate contents. Methods： The animal models of hypothyroid and hyperthyroid were reproduced. To exam the T3,T4,TSH,calcium and phosphate contents in serum. Results： T3, T4 and TSH in serum of the hypothyroid rats were 0. 27 ±0. 08nmol/L, 25.87±2. 83nmol/L and 3. 36±0. 42mU/L respectively. Comparing with the control rats, which T3 and T4 in serum were 0. 97±0.11nmol/L and 68. 74±7. 57nmol/L respectively, T3 and T4 in serum of hypothyroid group were obviously decreased（P〈0. 0001）; The content of TSH in serum of hypothyroid group obviously inereased（P〈0. 0001）. The content of TSH in serum of the control rats was 1.72±0.43mU/L. T3 and T4 in serum of the hyperthyroid rats were 9. 24 ± 1. 56nmol/L and 155. 73 ± 13. 98nmol/L respectively; Compared with the control group, the contents obviously increased （P〈0. 0001）, the content of TSH in serum of the hyperthyroid rats was 0. 37 ± 0. 06mU/L. Compared with the control group, the contents obviously decreased （P 〈 0.0001）. The concentrations of serum calcium （Ca^2＋） and serum phosphate （HPO4^2-） of the control group were 2. 37 ± 0. 30mmol/L and 2. 56 ± 0. 10mmol/L respectively; The concentrations of calcium and phosphate in serum of the hypothyroid rats were 2.27±0.15mmol/L and 2.33 ±0.10mmol/L respectively;The concentrations of calcium and phosphate in serum of the hyperthyroid rats were 6.17±1.42mmol/L and 3. 84±1.13mmol/L respectively. Conclusions： The concentration of Ca^2＋ and HPO4^2- in serum of the hyperthyroid rats obviously increased. Compared with the control group, the concentration of Ca^2＋ and HPO4^2- in serum of the hypothyroid rats decreased, but there were no significant differences.

关 键 词：甲状腺功能低下 甲状腺功能亢进 T3 T4 TSH 血钙 血磷 

分 类 号：R362[医药卫生—病理学]