^（51）Cr标记癌细胞检测癌转移及^（51）Cr在鼠体内的分布  

DETECTION OF METASTASIS OF CANCER CELL LABELLED BY^(51)Cr AND DISTRIBUTION OF ￣(51)Cr IN MICE

作　　者：朱启建 张琦 夏玉祥 朱金昌 陈国荣 邵黎明 胡芸 

出　　处：《温州医学院学报》1996年第1期4-7,共4页Journal of Wenzhou Medical College

摘　　要：用（５１）Ｃｒ标记Ｕ１４腹水癌细胞后移植于小鼠的足垫，动态检测了（５１）Ｃｒ在体内的分布及释放规律，同时用病理切片观察癌细胞的转移过程。结果：①（５１）Ｃｒ作为示踪剂标记肿瘤细胞，可作为检测动物癌细胞转移的方法，并比病理切片早获得转移的信息。②本文较详细地检测了（５１）Ｃｒ在体内的分布序列及排泄规律。③肿瘤细胞的繁殖能力越强，浓集（５１）Ｃｒ的能力也越强；并且这些浓集的（５１）Ｃｒ可随着细胞的分裂而转移给予细胞；癌细胞变性、坏死后代谢降低，浓集（５１）Ｃｒ的能力减弱或丧失。这可借以判断实验治疗的效果。he asoitic tumor cell of U14 labelled with 51Cr was transplanted into footpads of mice.The distribution and the releasing regularity of 51Cr in the body were dynamically inspected,and the metastatic processes were observed with patholgical section,The results showed:51Cr used as a radiorc aer to label the cancer cell could be regarded as the method of examining matastasis of the animal cancer cell,which could get cancer metastatic message earlier than the rountine section;2.The distributive sequence and the excretive regularity of 51Cr in body were studied in more details;3.The more multiplication of canoer cell,the greater concentration ability for 51Cr would be,and these51cr concentrations could be transmitted to the cells of filial eneration by cellular fission.After the degeneration or necrosis of the cancer cells the metabolic activity of cells would be declined and the concentration ability for 51Cr reduced or lost.Therefore,it could be used to assess the effects of experimental treatment.

关 键 词：放射性同位素 癌细胞 肿瘤转移 铬51 

分 类 号：R730.44[医药卫生—肿瘤]