300例乳腺癌三种性激素受体的检测和分析  

The Examination and Analysis on Three of Sexual Hormone Reaceptor in 300 Cases Breast Carcinoma

作　　者：马去非[1] 詹明[1] 王毅静[1] 赵俊卿[1] 夏玉璞 刘明[1] 霍增俊 

机构地区：[1]呼和浩特铁路局中心医院病理科,内蒙古自治区医院肿瘤科,内蒙古医学院附一院肿瘤科病理室,内蒙武警医院病理科

出　　处：《铁道医学》1996年第3期138-140,共3页Railway Medical Journal

摘　　要：采用直接荧光组织化学法对３００例女性乳腺癌进行三种性激素受体（雌激素受体ＥＲ、孕激素受体ＰＲ、雄激素受体ＡＲ）检测，结果ＥＲ、ＰＲ、ＡＲ阳性率分别为６１．６％、３８．３％和２２％．ＰＲ与ＥＲ阳性一致率为９８．３％，而ＡＲ与ＥＲ阳性一致率仅为５７．６％．本组结果显示乳腺癌硬癌性激素受体（ＨＲ）状况与年龄、肿瘤大小、组织学分级及腋淋巴结转移之间无相关性．而通常预后较差的非特殊型浸润性导管癌、单纯癌和ＨＲ阳性率高于其它各型乳腺癌，差异有显著性（Ｐ＜０．０５）．对４０例腋淋巴结转移癌ＨＲ检测结果表明，转移癌ＨＲ状况绝大多数与原发癌一致。Estrogen receptor (ER ), progestrerone receptor (PR) and androgen receptor (AR) in 300 cases of breast carinoma were measured by fluoresene steroid hormone conjugate technique (FSHCT). The positive rates for ER,PR and AR were 61. 6%,38. 3% and 22% respectiyely, The positive marching rate for PR and ER was 98. 3%,for AR and ER 57. 6%.The results did not show any interrelation among the HR properfies and age, size of the cancer,histological grade as well as the cancer histological grade as well as the metastasis to axillares lymphonodus. Otherwise,HR positive rates for nonspecific infiltrative carcinoma, simple carcinoma, solid carcinoma and scirrhous carcinoma were higher than those for the other types of carcinoma with significant difference (P<0. 05). The HR in 40 cases of axillary lymphonodi metastasis was mostly the same as that in the original carcinoma.

关 键 词：乳腺癌 性激素受体 测定 

分 类 号：R737.902[医药卫生—肿瘤]