慢性萎缩性胃炎胃粘膜肠化生及不典型增生临床分析  

Clinical analysis on chronic atrophic gastritis, stomach mucosa intestinal metaplasia and non - typical proliferation

作　　者：翁南星[1] 万群[1] 

机构地区：[1]厦门市第一医院杏林分院,福建厦门361022

出　　处：《现代保健（医学创新研究）》2006年第03X期1-3,共3页

摘　　要：目的慢性胃炎主要是由H．Pylori感染所引起的胃粘膜慢性炎症，多数是以胃窭为主的全胃炎。慢性萎缩性胃炎为常见胃粘膜屏障损害疾病，胃粘膜萎缩而被肠的上皮细胞取代即肠化生，炎症继续演变则细胞生长不典型，甚至癌变。本文通过病例分析，探讨慢性萎缩性胃炎病例中胃黏膜肠化生及不典型增生与不同年龄组、性别、HP感染等病理变化及相关临床症状，提供临床治疗参考。方法通过对慢性萎缩性胃炎（CAG）、胃粘膜肠化生及不典型增生病例胃镜检查结果、病理标本分析、症状对照，进行临床分析。结果表明CAG以中老年多见，青中年组中女性多于男性（P〈0．01），萎缩程度、肠化生率中老年组尤其是老年组偏高（P〈0．01）。HP感染时胃粘膜萎缩和肠化生的发生率显著高于无HP感染者（P〈0．01和P〈0．05）。但与胃粘膜不典型增生的发生率无显著差异（P〈0．05）。Objective Chronic gasIritis is stomach mucosa chromic inflammation, mainly infected by H. Pylori. The most of it is holo - gastritis that is most likely sinus ventriculy. Chronic atrophic gastritis is normally frequently seen that stomach mucosa barrier damages stomach. When it is atrophic gastritis, atrophy of stomach mucosa is replaced by epithelial cell, that is intestinal metaplasia; inflammation continues evolving, so cell grows non - typically,even cellular proliferation causes canceration. Methods The paper clinical analysis on chronic atrophic gastritis,stomach mucosa intestinal metaplasia and non - typical proliferation.Results Indicating that most of CAG is metu- gerontism,female being more than male （ P 〈 0.01 ） in youth middle aged teams, the rate of intestinal metaplasia being higher in gerontism of metu - gerontism teams（ P 〈 0.01 ）. When HP is infected, the rate of stomach mueosa atrophy and intestinal metaplasia is notable higher than those infected by HP（P 〈 0.01 and P 〈 0.05）, but it is not notably different with the rate of non- tvoical oroliferation（P 〈 0.05）.

关 键 词：慢性萎缩性胃炎 胃粘膜肠化生 不典型增生 临床分析 

分 类 号：R573.32[医药卫生—消化系统]